Cell Biology Antibodies 7
Anti-HEBP2 Antibody (CAB16504)
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- SKU:
- CAB16504
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HEBP2 Antibody |
| Antibody SKU: | CAB16504 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human HEBP2 (NP_055135.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | COS-7, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human HEBP2 (NP_055135.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEP LQPD PGAA EDAA AQAV ETPG WKAP EDAG PQPG SYEI RHYG PAKW VSTS VESM DWDS AIQT GFTK LNSY IQGK NEKE MKIK MTAP VTSY VEPG SGPF SEST ITIS LYIP SEQQ FDPP RPLE SDVF IEDR AEMT VFVR SFDG FSSA QKNQ EQLL TLAS ILRE DGKV FDEK VYYT AGYN SPVK LLNR NNEV WLIQ KNEP TKEN E |
| Gene ID: | 23593 |
| Uniprot: | Q9Y5Z4 |
| Cellular Location: | Cytoplasm, Mitochondrion |
| Calculated MW: | 20kDa/22kDa |
| Observed MW: | 25kDa |
| Synonyms: | HEBP2, C6ORF34B, C6orf34, PP23, SOUL |
| Background: | The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. |
| UniProt Protein Function: | HEBP2: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin. Belongs to the HEBP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q24 Cellular Component: cytoplasm; mitochondrion Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016] |
| UniProt Code: | Q9Y5Z4 |
| NCBI GenInfo Identifier: | 74753513 |
| NCBI Gene ID: | 23593 |
| NCBI Accession: | Q9Y5Z4.1 |
| UniProt Secondary Accession: | Q9Y5Z4,Q96P57, |
| UniProt Related Accession: | Q9Y5Z4 |
| Molecular Weight: | 20,859 Da |
| NCBI Full Name: | Heme-binding protein 2 |
| NCBI Synonym Full Names: | heme binding protein 2 |
| NCBI Official Symbol: | HEBP2 |
| NCBI Official Synonym Symbols: | PP23; SOUL; C6orf34; C6ORF34B |
| NCBI Protein Information: | heme-binding protein 2 |
| UniProt Protein Name: | Heme-binding protein 2 |
| UniProt Synonym Protein Names: | Placental protein 23; PP23; Protein SOUL |
| Protein Family: | Heme-binding protein |
| UniProt Gene Name: | HEBP2 |
| UniProt Entry Name: | HEBP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HEBP2 antibody (CAB16504) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded Rat spleen using HEBP2 Rabbit pAb (CAB16504) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse kidney using HEBP2 Rabbit pAb (CAB16504) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using HEBP2 antibody (CAB16504) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using HEBP2 antibody (CAB16504) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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