Epigenetics & Nuclear Signaling Antibodies 2
Anti-HDAC11 Antibody (CAB6140)
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- SKU:
- CAB6140
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-HDAC11 Antibody |
| Antibody SKU: | CAB6140 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-347 of human HDAC11 (NP_079103.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse small intestine, BT-474, MCF7, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-347 of human HDAC11 (NP_079103.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLSI SPAG IVKR DELV FRMV RGRR VPIL MVTS GGYQ KRTA RIIA DSIL NLFG LGLI GPES PSVS AQNS DTPL LPPA VP |
| Gene ID: | 79885 |
| Uniprot: | Q96DB2 |
| Cellular Location: | Nucleus |
| Calculated MW: | 33kDa/39kDa |
| Observed MW: | 39kDa |
| Synonyms: | HDAC11, HD11 |
| Background: | This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | HDAC11: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.5.1.98; Deacetylase Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: histone deacetylase complex; nucleus; plasma membrane Molecular Function:histone deacetylase activity; transcription factor binding Biological Process: chromatin modification; histone deacetylation |
| NCBI Summary: | This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009] |
| UniProt Code: | Q96DB2 |
| NCBI GenInfo Identifier: | 26394832 |
| NCBI Gene ID: | 79885 |
| NCBI Accession: | Q96DB2.1 |
| UniProt Secondary Accession: | Q96DB2,Q9H6I7, Q9H6X3, Q9NTC9, B4DDK1, |
| UniProt Related Accession: | Q96DB2 |
| Molecular Weight: | 33,124 Da |
| NCBI Full Name: | Histone deacetylase 11 |
| NCBI Synonym Full Names: | histone deacetylase 11 |
| NCBI Official Symbol: | HDAC11 |
| NCBI Official Synonym Symbols: | HD11 |
| NCBI Protein Information: | histone deacetylase 11 |
| UniProt Protein Name: | Histone deacetylase 11 |
| Protein Family: | Histone deacetylase |
| UniProt Gene Name: | HDAC11 |
| UniProt Entry Name: | HDA11_HUMAN |
 | Western blot analysis of extracts of mouse small intestine, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Western blot analysis of extracts of various cell lines, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Western blot analysis of extracts of various cell lines, using HDAC11 antibody (CAB6140) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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