UniProt Protein Function: | Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. |
NCBI Summary: | This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBK5 |
NCBI GenInfo Identifier: | 74734930 |
NCBI Gene ID: | 10870 |
NCBI Accession: | Q9UBK5.1 |
UniProt Related Accession: | Q9UBK5 |
Molecular Weight: | 9kDa |
NCBI Full Name: | Hematopoietic cell signal transducer |
NCBI Synonym Full Names: | hematopoietic cell signal transducer |
NCBI Official Symbol: | HCST |
NCBI Official Synonym Symbols: | DAP10; KAP10; PIK3AP |
NCBI Protein Information: | hematopoietic cell signal transducer |
UniProt Protein Name: | Hematopoietic cell signal transducer |
UniProt Synonym Protein Names: | DNAX-activation protein 10; Membrane protein DAP10; Transmembrane adapter protein KAP10 |
Protein Family: | Hematopoietic cell signal transducer |
UniProt Gene Name: | HCST |