Cell Biology Antibodies 18
Anti-HCN2 Antibody (CAB18339)
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- SKU:
- CAB18339
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HCN2 Antibody |
| Antibody SKU: | CAB18339 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human HCN2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human HCN2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 610 |
| Uniprot: | Q9UL51 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | BCNG-2, BCNG2, HAC-1, HCN2 |
| Background: |
| UniProt Protein Function: | HCN2: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Belongs to the potassium channel HCN family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, cation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:cAMP binding; identical protein binding; intracellular cAMP activated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity Biological Process: cell-cell signaling; regulation of membrane potential; synaptic transmission |
| NCBI Summary: | Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010] |
| UniProt Code: | Q9UL51 |
| NCBI GenInfo Identifier: | 108935843 |
| NCBI Gene ID: | 610 |
| NCBI Accession: | Q9UL51.3 |
| UniProt Secondary Accession: | Q9UL51,O60742, O60743, O75267, Q9UBS2, |
| UniProt Related Accession: | Q9UL51 |
| Molecular Weight: | 96,950 Da |
| NCBI Full Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
| NCBI Synonym Full Names: | hyperpolarization activated cyclic nucleotide gated potassium channel 2 |
| NCBI Official Symbol: | HCN2 |
| NCBI Official Synonym Symbols: | BCNG2; HAC-1; BCNG-2 |
| NCBI Protein Information: | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
| UniProt Protein Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
| UniProt Synonym Protein Names: | Brain cyclic nucleotide-gated channel 2; BCNG-2 |
| Protein Family: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
| UniProt Gene Name: | HCN2 |
| UniProt Entry Name: | HCN2_HUMAN |
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