Cell Cycle Antibodies 1
Anti-HCFC1 Antibody (CAB1841)
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- SKU:
- CAB1841
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-HCFC1 Antibody |
| Antibody SKU: | CAB1841 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human HCFC1 (NP_005325.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HeLa, Jurkat, A-431, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human HCFC1 (NP_005325.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASA VSPA NLPA VLLQ PRWK RVVG WSGP VPRP RHGH RAVA IKEL IVVF GGGN EGIV DELH VYNT ATNQ WFIP AVRG DIPP GCAA YGFV CDGT RLLV FGGM VEYG KYSN DLYE LQAS RWEW KRLK AKTP KNGP PPCP RLGH SFSL VGNK CYLF GGLA NDSE DPKN NIPR YLND LYIL ELRP GSGV VAWD IPIT YGVL PPPR ESHT AVVY TEKD NKKS KLVI YGGM SGCR LGDL WTLD IDTL TWNK PSLS GV |
| Gene ID: | 3054 |
| Uniprot: | P51610 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 47kDa/201kDa/208kDa/213kDa |
| Observed MW: | 100-260kDa |
| Synonyms: | HCFC1, CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF |
| Background: | This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| UniProt Protein Function: | HCFC1: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xq28 Cellular Component: nucleoplasm; membrane; cell soma; mitochondrion; cytoplasm; nucleus; histone acetyltransferase complex Molecular Function:identical protein binding; protein binding; transcription coactivator activity; chromatin binding; histone acetyltransferase activity (H4-K16 specific); transcription factor activity Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; establishment and/or maintenance of chromatin architecture; protein stabilization; regulation of transcription, DNA-dependent; organelle organization and biogenesis; reactivation of latent virus; positive regulation of cell cycle; regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell cycle Disease: Methylmalonic Acidemia And Homocysteinemia, Cblx Type |
| NCBI Summary: | This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51610 |
| NCBI GenInfo Identifier: | 160332311 |
| NCBI Gene ID: | 3054 |
| NCBI Accession: | P51610.2 |
| UniProt Secondary Accession: | P51610,Q6P4G5, |
| UniProt Related Accession: | P51610,AAB27583 |
| Molecular Weight: | 2035 |
| NCBI Full Name: | Host cell factor 1 |
| NCBI Synonym Full Names: | host cell factor C1 |
| NCBI Official Symbol: | HCFC1 |
| NCBI Official Synonym Symbols: | CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89 |
| NCBI Protein Information: | host cell factor 1; VP16-accessory protein; protein phosphatase 1, regulatory subunit 89 |
| UniProt Protein Name: | Host cell factor 1 |
| UniProt Synonym Protein Names: | C1 factor; CFF; VCAF; VP16 accessory proteinCleaved into the following 12 chains:HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6 |
| Protein Family: | Host cell factor |
| UniProt Gene Name: | HCFC1 |
| UniProt Entry Name: | HCFC1_HUMAN |
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