Signal Transduction Antibodies 3

Anti-HBZ Antibody (CAB6920)

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SKU:
CAB6920
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-HBZ Antibody
Antibody SKU:CAB6920
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human HBZ (NP_005323.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human HBZ (NP_005323.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSLT KTER TIIV SMWA KIST QADT IGTE TLER LFLS HPQT KTYF PHFD LHPG SAQL RAHG SKVV AAVG DAVK SIDD IGGA LSKL SELH AYIL RVDP VNFK LLSH CLLV TLAA RFPA DFTA EAHA AWDK FLSV VSSV LTEK YR
Gene ID:3050
Uniprot:P02008
Cellular Location:
Calculated MW:15kDa
Observed MW:13kDa
Synonyms:HBZ, HBZ-T1, HBZ1
Background:Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.
UniProt Protein Function:HBZ: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac. Belongs to the globin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: hemoglobin complex

Molecular Function:protein binding; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: erythrocyte maturation; oxygen transport; negative regulation of transcription from RNA polymerase II promoter

UniProt Code:P02008
NCBI GenInfo Identifier:122335
NCBI Gene ID:
NCBI Accession:P02008.2
Molecular Weight:
NCBI Full Name:Hemoglobin subunit zeta
UniProt Protein Name:Hemoglobin subunit zeta
UniProt Synonym Protein Names:HBAZ; Hemoglobin zeta chain; Zeta-globin
Protein Family:Hemoglobin
UniProt Gene Name:HBZ  
UniProt Entry Name:HBAZ_HUMAN
Anti-HBZ Antibody (CAB6920)Western blot analysis of extracts of K-562 cells, using HBZ Antibody (CAB6920) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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