Metabolism Antibodies 1

Anti-HBS1L Antibody (CAB10037)

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SKU:
CAB10037
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-HBS1L Antibody
Antibody SKU:CAB10037
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human HBS1L (NP_006611.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:NIH/3T3, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human HBS1L (NP_006611.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MARH RNVR GYNY DEDF EDDD LYGQ SVED DYCI SPST AAQF IYSR RDKP SVEP VEEY DYED LKES SNSV SNHQ LSGF DQAR LYSC LDHM REVL GDAV PDEI LIEA VLKN KFDV QKAL SGVL EQDR VQSL KDKN EATV STGK IAKG KPVD SQTS RSES EIVP KVAK MTVS GKKQ TMGF EVPG VSSE ENGH SFHT PQKG PPIE DAIA SSDV LETA SKSA NPPH TIQA SEEQ SSTP APVK KSGK LRQQ IDVK AELE KRQG GKQL
Gene ID:10767
Uniprot:Q9Y450
Cellular Location:
Calculated MW:70kDa/75kDa
Observed MW:75kDa
Synonyms:HBS1L, EF-1a, ERFS, HBS1, HSPC276, eRF3c
Background:This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
UniProt Protein Function:HBS1: a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Protein Details:

Protein type:Translation; Translation elongation; RNA-binding

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: intracellular; membrane

Molecular Function:GTPase activity

Biological Process: ribosome disassembly; signal transduction; translation

NCBI Summary:This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Code:Q9Y450
NCBI GenInfo Identifier:68566500
NCBI Gene ID:10767
NCBI Accession:Q9Y450.1
UniProt Secondary Accession:Q9Y450,Q4VX89, Q4VX90, Q5T7G3, Q8NDW9, Q9UPW3, B7Z365
UniProt Related Accession:Q9Y450
Molecular Weight:70,625 Da
NCBI Full Name:HBS1-like protein
NCBI Synonym Full Names:HBS1 like translational GTPase
NCBI Official Symbol:HBS1L  
NCBI Official Synonym Symbols:ERFS; HBS1; EF-1a; eRF3c; HSPC276  
NCBI Protein Information:HBS1-like protein
UniProt Protein Name:HBS1-like protein
UniProt Synonym Protein Names:ERFS
Protein Family:HBS1-like protein
UniProt Gene Name:HBS1L  
UniProt Entry Name:HBS1L_HUMAN
Anti-HBS1L Antibody (CAB10037)Western blot analysis of extracts of various cell lines, using HBS1L antibody (CAB10037) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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