Epigenetics & Nuclear Signaling Antibodies 3
Anti-HBP1 Antibody (CAB14672)
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- SKU:
- CAB14672
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-HBP1 Antibody |
| Antibody SKU: | CAB14672 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human HBP1 (NP_036389.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FLKG TRLC FHKG SNKE WQDV EDFA RAEG CDNE EDLQ MGIH KGYG SDGL KLLS HEES VSFG ESVL KLTF DPGT VEDG LLTV ECKL DHPF YVKN KGWS SFYP SLTV VQHG IPCC EVHI GDVC LPPG HPDA INFD DSGV FDTF KSYD FTPM DSSA VYVL SSMA RQRR ASLS CGGP GGQD FARS GFSK NCGS PGSS QLSS NSLY AKAV KNHS SGTV SATS PNKC KRPM NAFM LFAK KYRV EYTQ MYPG KDNR AISV ILGD RWKK MKNE ERRM YTLE AKAL AEEQ KRLN PDCW KRKR TNSG SQQH |
| Gene ID: | 26959 |
| Uniprot: | O60381 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa/57kDa |
| Observed MW: | 58kDa |
| Synonyms: | HBP1 |
| Background: |
| UniProt Protein Function: | HBP1: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 7q22.3 Cellular Component: nucleoplasm Molecular Function:protein binding; DNA binding; RNA binding Biological Process: Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of potassium ion transport; cell cycle arrest |
| UniProt Code: | O60381 |
| NCBI GenInfo Identifier: | 346716352 |
| NCBI Gene ID: | 26959 |
| NCBI Accession: | NP_001231191.1 |
| UniProt Secondary Accession: | O60381,Q8TBM1, Q8TE93, Q96AJ2, B3KVB7, |
| UniProt Related Accession: | O60381 |
| Molecular Weight: | 57,645 Da |
| NCBI Full Name: | HMG box-containing protein 1 isoform 1 |
| NCBI Synonym Full Names: | HMG-box transcription factor 1 |
| NCBI Official Symbol: | HBP1 |
| NCBI Protein Information: | HMG box-containing protein 1; HMG box transcription factor 1; high mobility group box transcription factor 1 |
| UniProt Protein Name: | HMG box-containing protein 1 |
| UniProt Synonym Protein Names: | HMG box transcription factor 1; High mobility group box transcription factor 1 |
| Protein Family: | HMG box-containing protein |
| UniProt Gene Name: | HBP1 |
| UniProt Entry Name: | HBP1_HUMAN |
 | Western blot analysis of extracts of rat brain, using HBP1 antibody (CAB14672) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
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