Signal Transduction Antibodies 2
Anti-HBG1 Antibody (CAB14989)
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- SKU:
- CAB14989
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-HBG1 Antibody |
| Antibody SKU: | CAB14989 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HBG1 (NP_000550.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, K-562 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HBG1 (NP_000550.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGHF TEED KATI TSLW GKVN VEDA GGET LGRL LVVY PWTQ RFFD SFGN LSSA SAIM GNPK VKAH GKKV LTSL GDAT KHLD DLKG TFAQ LSEL HCDK LHVD |
| Gene ID: | 3047 |
| Uniprot: | P69891 |
| Cellular Location: | |
| Calculated MW: | 16kDa |
| Observed MW: | 12KDa |
| Synonyms: | HBG1, HBG-T2, HBGA, HBGR, HSGGL1, PRO2979 |
| Background: | The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. |
| UniProt Protein Function: | HBG1: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Belongs to the globin family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytosol Biological Process: blood coagulation Disease: Fetal Hemoglobin Quantitative Trait Locus 1 |
| NCBI Summary: | The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P69891 |
| NCBI GenInfo Identifier: | 56749860 |
| NCBI Gene ID: | 3047 |
| NCBI Accession: | P69891.2 |
| UniProt Secondary Accession: | P69891,P02096, P62027, Q549G1, Q8TDA1, Q96FH7, |
| UniProt Related Accession: | P69891 |
| Molecular Weight: | 16,140 Da |
| NCBI Full Name: | Hemoglobin subunit gamma-1 |
| NCBI Synonym Full Names: | hemoglobin subunit gamma 1 |
| NCBI Official Symbol: | HBG1 |
| NCBI Official Synonym Symbols: | HBGA; HBGR; HBG-T2; HSGGL1; PRO2979 |
| NCBI Protein Information: | hemoglobin subunit gamma-1 |
| UniProt Protein Name: | Hemoglobin subunit gamma-1 |
| UniProt Synonym Protein Names: | Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain |
| Protein Family: | Hemoglobin |
| UniProt Gene Name: | HBG1 |
| UniProt Entry Name: | HBG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HBG1 Rabbit pAb (CAB14989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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