Signal Transduction Antibodies 2

Anti-HBE1 Antibody (CAB3909)

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SKU:
CAB3909
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-HBE1 Antibody
Antibody SKU:CAB3909
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBE1 (NP_005321.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human HBE1 (NP_005321.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVHF TAEE KAAV TSLW SKMN VEEA GGEA LGRL LVVY PWTQ RFFD SFGN LSSP SAIL GNPK VKAH GKKV LTSF GDAI KNMD NLKP AFAK LSEL HCDK LHVD PENF KLLG NVMV IILA THFG KEFT PEVQ AAWQ KLVS AVAI ALAH KYH
Gene ID:3046
Uniprot:P02100
Cellular Location:
Calculated MW:16kDa
Observed MW:12kDa
Synonyms:HBE1, HBE
Background:The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'
UniProt Protein Function:HBE1: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. Belongs to the globin family.
UniProt Protein Details:

Protein type:Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; cytosol

Molecular Function:iron ion binding; heme binding; hemoglobin alpha binding; oxygen binding; oxygen transporter activity

Biological Process: oxygen transport; protein heterooligomerization; negative regulation of transcription from RNA polymerase II promoter; blood coagulation

NCBI Summary:The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
UniProt Code:P02100
NCBI GenInfo Identifier:122726
NCBI Gene ID:3046
NCBI Accession:P02100.2
UniProt Related Accession:P02100
Molecular Weight:
NCBI Full Name:Hemoglobin subunit epsilon
NCBI Synonym Full Names:hemoglobin subunit epsilon 1
NCBI Official Symbol:HBE1  
NCBI Official Synonym Symbols:HBE  
NCBI Protein Information:hemoglobin subunit epsilon
UniProt Protein Name:Hemoglobin subunit epsilon
UniProt Synonym Protein Names:Epsilon-globin; Hemoglobin epsilon chain
UniProt Gene Name:HBE1  
UniProt Entry Name:HBE_HUMAN
Anti-HBE1 Antibody (CAB3909)Western blot analysis of extracts of K-562 cells, using HBE1 antibody (CAB3909) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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