Immunology Antibodies 2
Anti-HAVCR1 Antibody (CAB2831)
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- SKU:
- CAB2831
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-HAVCR1 Antibody |
| Antibody SKU: | CAB2831 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-120 of human HAVCR1 (NP_036338.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | RAW 264.7, Jurkat, PC12, mouse spleen, mouse kidney, rat testis, rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-120 of human HAVCR1 (NP_036338.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SVKV GGEA GPSV TLPC HYSG AVTS MCWN RGSC SLFT CQNG IVWT NGTH VTYR KDTR YKLL GDLS RRDV SLTI ENTA VSDS GVYC CRVE HRGW FNDM KITV |
| Gene ID: | 26762 |
| Uniprot: | Q96D42 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 50kDa |
| Synonyms: | HAVCR1, CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 |
| Background: | The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. |
| UniProt Protein Function: | TIM-1: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Belongs to the immunoglobulin superfamily. TIM family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33.2 Cellular Component: integral to membrane Molecular Function:viral receptor activity Biological Process: entry of virus into host cell Disease: Ige Responsiveness, Atopic |
| NCBI Summary: | The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96D42 |
| NCBI GenInfo Identifier: | 73919877 |
| NCBI Gene ID: | 26762 |
| NCBI Accession: | Q96D42.2 |
| UniProt Secondary Accession: | Q96D42,O43656, |
| UniProt Related Accession: | Q96D42 |
| Molecular Weight: | 364 |
| NCBI Full Name: | Hepatitis A virus cellular receptor 1 |
| NCBI Synonym Full Names: | hepatitis A virus cellular receptor 1 |
| NCBI Official Symbol: | HAVCR1 |
| NCBI Official Synonym Symbols: | TIM; KIM1; TIM1; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1 |
| NCBI Protein Information: | hepatitis A virus cellular receptor 1; kidney injury molecule 1; T-cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; T-cell immunoglobulin mucin family member 1; T cell immunoglobin domain and mucin domain protein 1 |
| UniProt Protein Name: | Hepatitis A virus cellular receptor 1 |
| UniProt Synonym Protein Names: | Kidney injury molecule 1; KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T-cell immunoglobulin mucin receptor 1; TIM; TIM-1; T-cell membrane protein 1 |
| UniProt Gene Name: | HAVCR1 |
| UniProt Entry Name: | HAVR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HAVCR1 antibody (CAB2831) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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