Cell Biology Antibodies 17
Anti-HAUSP / USP7 Antibody (CAB3448)
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- SKU:
- CAB3448
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HAUSP / USP7 Antibody |
| Antibody SKU: | CAB3448 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HAUSP / USP7 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, PC-3, Mouse testis, Mouse brain, Rat testis, Rat brain |
| Immunogen: | A synthesized peptide derived from human HAUSP / USP7 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7874 |
| Uniprot: | Q93009 |
| Cellular Location: | |
| Calculated MW: | 128kDa |
| Observed MW: | 140KDa |
| Synonyms: | HAUSP, TEF1 |
| Background: | The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016] |
| UniProt Protein Function: | USP7: an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. |
| UniProt Protein Details: | Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nuclear body; PML body; cytosol; nucleus Molecular Function:protein C-terminus binding; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; maintenance of DNA methylation; viral reproduction; regulation of transcription factor activity; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development; histone deubiquitination |
| UniProt Code: | Q93009 |
| NCBI GenInfo Identifier: | 212276477 |
| NCBI Gene ID: | 7874 |
| NCBI Accession: | Q93009.2 |
| UniProt Secondary Accession: | Q93009,A6NMY8, B7Z815, H0Y3G8, |
| UniProt Related Accession: | Q93009 |
| Molecular Weight: | 1102 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 7 (herpes virus-associated) |
| NCBI Official Symbol: | USP7 |
| NCBI Official Synonym Symbols: | TEF1; HAUSP |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin spec |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7 |
| UniProt Gene Name: | USP7 |
| UniProt Entry Name: | UBP7_HUMAN |
 | Western blot - HAUSP / USP7 Rabbit mAb (CAB3448) |
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