Cell Cycle Antibodies 1

Anti-HAUS6 Antibody (CAB4797)

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SKU:
CAB4797
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HAUS6
Synonyms:
Dgt6
Synonyms:
FAM29A
Research Area:
Cell Cycle

Description

Product Name:HAUS6 Rabbit pAb
Product Code:CAB4797
Size:20uL, 50uL, 100uL
Synonyms:HAUS6, Dgt6, FAM29A
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 676-955 of human HAUS6 (NP_060115.3).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse spleen, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 676-955 of human HAUS6 (NP_060115.3).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DEPP TQNQ SDLL NKKV ICKQ DLEC LAFT KLSE TSRM ETFS PAVG NRID VMGG SEEE FMKI LDHL EVSC NKPS TNKT MLWN SFQI SSGI SSKS FKDN DFGI LHET LPEE VGHL SFNS SSSS EANF KLEP NSPM HGGT LLED VVGG RQTT PESD FNLQ ALRS RYEA LKKS LSKK REES YLSN SQTP ERHK PELS PTPQ NVQT DDTL NFLD TCDL HTEH IKPS LRTS IGER KRSL SPLI KFSP VEQR LRTT IACS LGEL PNLK EEDI LNKS LDAK EPPS DLTR
Gene ID:54801
Uniprot:Q7Z4H7
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle
Calculated MW:69kDa/104kDa/108kDa
Observed MW:109kDa
UniProt Protein Function:HAUS6: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. Belongs to the HAUS6 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: nucleoplasm; microtubule; centrosome; cytoplasm; microtubule organizing center; spindle

Biological Process: mitosis; cell division; centrosome organization and biogenesis; spindle assembly

NCBI Summary:The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
UniProt Code:Q7Z4H7
NCBI GenInfo Identifier:85700957
NCBI Gene ID:54801
NCBI Accession:Q7Z4H7.2
UniProt Secondary Accession:Q7Z4H7,Q05CG1, Q14CB6, Q14CD9, Q2TA91, Q6IQ10, Q6NZX5 Q8IZQ4, Q96FN0, Q9H950, B3KPK4, B4DX82,
UniProt Related Accession:Q7Z4H7
Molecular Weight:955
NCBI Full Name:HAUS augmin-like complex subunit 6
NCBI Synonym Full Names:HAUS augmin-like complex, subunit 6
NCBI Official Symbol:HAUS6  
NCBI Official Synonym Symbols:Dgt6; FAM29A  
NCBI Protein Information:HAUS augmin-like complex subunit 6; dim gamma-tubulin homolog; family with sequence similarity 29, member A
UniProt Protein Name:HAUS augmin-like complex subunit 6
Protein Family:HAUS augmin-like complex
UniProt Gene Name:HAUS6  
UniProt Entry Name:HAUS6_HUMAN
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