Cell Biology Antibodies 10
Anti-HAS3 Antibody (CAB6617)
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- SKU:
- CAB6617
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HAS3 Antibody |
| Antibody SKU: | CAB6617 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HL-60, SKOV3, SW480, Mouse heart, Rat liver, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 67-281 of human HAS3 (NP_619515.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HRRM RRAG QALK LPSP RRGS VALC IAAY QEDP DYLR KCLR SAQR ISFP DLKV VMVV DGNR QEDA YMLD IFHE VLGG TEQA GFFV WRSN FHEA GEGE TEAS LQEG MDRV RDVV RAST FSCI MQKW GGKR EVMY TAFK ALGD SVDY IQVC DSDT VLDP ACTI EMLR VLEE DPQV GGVG GDVQ PPGK GMAV EDDQ VQAA QVRA TEAW SVHQ RHVS REQ |
| Gene ID: | 3038 |
| Uniprot: | O00219 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 31kDa/62kDa |
| Observed MW: | 73kDa |
| Synonyms: | HAS3 |
| Background: | The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | HAS3: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Belongs to the NodC/HAS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 2.4.1.212; Transferase; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:hyaluronan synthase activity Biological Process: carbohydrate metabolic process; cell adhesion; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O00219 |
| NCBI GenInfo Identifier: | 206729920 |
| NCBI Gene ID: | 3038 |
| NCBI Accession: | O00219.3 |
| UniProt Secondary Accession: | O00219,Q8WTZ0, Q9NYP0, A8K5T5, |
| UniProt Related Accession: | O00219 |
| Molecular Weight: | 31,200 Da |
| NCBI Full Name: | Hyaluronan synthase 3 |
| NCBI Synonym Full Names: | hyaluronan synthase 3 |
| NCBI Official Symbol: | HAS3 |
| NCBI Protein Information: | hyaluronan synthase 3 |
| UniProt Protein Name: | Hyaluronan synthase 3 |
| UniProt Synonym Protein Names: | Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3 |
| Protein Family: | Hyaluronan synthase |
| UniProt Gene Name: | HAS3 |
| UniProt Entry Name: | HYAS3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HAS3 antibody (CAB6617) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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