Metabolism Antibodies 2
Anti-HAAO Antibody (CAB4559)
- SKU:
- CAB4559
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HAAO
- Synonyms:
- 3-HAO
- Synonyms:
- HAO
- Research Area:
- Metabolism
Description
| Product Name: | HAAO Rabbit pAb |
| Product Code: | CAB4559 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HAAO, 3-HAO, HAO |
| Applications: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse spleen, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MERR LGVR AWVK ENRG SFQP PVCN KLMH QEQL KVMF IGGP NTRK DYHI EEGE EVFY QLEG DMVL RVLE QGKH RDVV IRQG EIFL LPAR VPHS PQRF ANTV GLVV ERRR LETE LDGL RYYV GDTM DVLF EKWF YCKD LGTQ LAPI IQEF FSSE QYRT GKPI PDQL LKEP PFPL STRS IMEP MSLD AWLD SHHR ELQA GTPL SLFG DTYE TQVI AYGQ GSSE GLRQ NVDV WLWQ LEGS SVVT MGGR RLSL APDD SLLV LAGT SYAW ERTQ GSVA LSVT QDPA CKKP LG |
| Gene ID: | 23498 |
| Uniprot: | P46952 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 17kDa/32kDa |
| Observed MW: | 32kDa |
| UniProt Protein Function: | HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.13.11.6 Chromosomal Location of Human Ortholog: 2p21 Cellular Component: mitochondrial membrane; cytosol Molecular Function:electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process |
| NCBI Summary: | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46952 |
| NCBI GenInfo Identifier: | 308153402 |
| NCBI Gene ID: | 23498 |
| NCBI Accession: | P46952.2 |
| UniProt Secondary Accession: | P46952,Q53QZ7, Q8N6N9, A6NE56, B4DIN2, |
| UniProt Related Accession: | P46952 |
| Molecular Weight: | 17,275 Da |
| NCBI Full Name: | 3-hydroxyanthranilate 3,4-dioxygenase |
| NCBI Synonym Full Names: | 3-hydroxyanthranilate 3,4-dioxygenase |
| NCBI Official Symbol: | HAAO |
| NCBI Official Synonym Symbols: | HAO; 3-HAO |
| NCBI Protein Information: | 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase |
| UniProt Protein Name: | 3-hydroxyanthranilate 3,4-dioxygenase |
| UniProt Synonym Protein Names: | 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD |
| UniProt Gene Name: | HAAO |
| UniProt Entry Name: | 3HAO_HUMAN |
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