Metabolism Antibodies 2

Anti-HAAO Antibody (CAB4559)

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CAB4559

Description

Product Name:HAAO Rabbit pAb
Product Code:CAB4559
Size:20uL, 50uL, 100uL
Synonyms:HAAO, 3-HAO, HAO
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MERR LGVR AWVK ENRG SFQP PVCN KLMH QEQL KVMF IGGP NTRK DYHI EEGE EVFY QLEG DMVL RVLE QGKH RDVV IRQG EIFL LPAR VPHS PQRF ANTV GLVV ERRR LETE LDGL RYYV GDTM DVLF EKWF YCKD LGTQ LAPI IQEF FSSE QYRT GKPI PDQL LKEP PFPL STRS IMEP MSLD AWLD SHHR ELQA GTPL SLFG DTYE TQVI AYGQ GSSE GLRQ NVDV WLWQ LEGS SVVT MGGR RLSL APDD SLLV LAGT SYAW ERTQ GSVA LSVT QDPA CKKP LG
Gene ID:23498
Uniprot:P46952
Cellular Location:Cytoplasm
Calculated MW:17kDa/32kDa
Observed MW:32kDa
UniProt Protein Function:HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.13.11.6

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: mitochondrial membrane; cytosol

Molecular Function:electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity

Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process

NCBI Summary:3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
UniProt Code:P46952
NCBI GenInfo Identifier:308153402
NCBI Gene ID:23498
NCBI Accession:P46952.2
UniProt Secondary Accession:P46952,Q53QZ7, Q8N6N9, A6NE56, B4DIN2,
UniProt Related Accession:P46952
Molecular Weight:17,275 Da
NCBI Full Name:3-hydroxyanthranilate 3,4-dioxygenase
NCBI Synonym Full Names:3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Symbol:HAAO  
NCBI Official Synonym Symbols:HAO; 3-HAO  
NCBI Protein Information:3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase
UniProt Protein Name:3-hydroxyanthranilate 3,4-dioxygenase
UniProt Synonym Protein Names:3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD
UniProt Gene Name:HAAO  
UniProt Entry Name:3HAO_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HAAO
Synonyms:
3-HAO
Synonyms:
HAO
Research Area:
Metabolism
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