| Synonyms: | GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 |
| Background: | Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. |
| UniProt Protein Function: | Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). |
| NCBI Summary: | Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02724 |
| NCBI GenInfo Identifier: | 259016238 |
| NCBI Gene ID: | 2993 |
| NCBI Accession: | P02724.2 |
| UniProt Secondary Accession: | P02724,Q9BS51, A8K3E6, B8Q182, B8Q185, |
| UniProt Related Accession: | P02724 |
| Molecular Weight: | 13,000 Da |
| NCBI Full Name: | Glycophorin-A |
| NCBI Synonym Full Names: | glycophorin A (MNS blood group) |
| NCBI Official Symbol: | GYPA |
| NCBI Official Synonym Symbols: | MN; GPA; MNS; GPSAT; PAS-2; CD235a; GPErik; HGpMiV; HGpMiXI; HGpSta(C) |
| NCBI Protein Information: | glycophorin-A |
| UniProt Protein Name: | Glycophorin-A |
| UniProt Synonym Protein Names: | MN sialoglycoprotein; PAS-2; Sialoglycoprotein alpha; CD_antigen: CD235a |
| Protein Family: | Glycophorin |
| UniProt Gene Name: | GYPA |
![GYPA Monoclonal Antibody [NYRhGlycophorinA] (CPAB0493)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58715/63897/gypa-monoclonal-antibody-nyrhglycophorina-cpab0493__81691__22424.1706535193.jpg?c=1 "GYPA Monoclonal Antibody [NYRhGlycophorinA] (CPAB0493)")
