Antibody Name:	Anti-GUCY2F Antibody
Antibody SKU:	CAB14243
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	HSAL IGGE TQMH LLEC AHDL KMTD GTYV FVPY DALL YSLP YKHT PYRV LRNN PKLR EAYD AVLT ITVE SQEK TFYQ AFTE AAAR GEIP EKLE FDQV SPLF GTIY NSIY FIAQ AMNN AMKE NGQA GAAS LVQH SRNM QFHG FNQL MRTD SNGN GISE YVIL DTNL KEWE LHST YTVD MEME LLRF GGTP IHFP GGRP PRAD AKCW FAEG KIC
Gene ID:	2986
Uniprot:	P51841
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	124kDa
Observed MW:	Refer to Figures

Synonyms:

GUCY2F, CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2

Background:

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.

UniProt Protein Function:	GUCY2F: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
UniProt Protein Details:	Protein type:Protein kinase, dual-specificity (receptor); Receptor, misc.; Kinase, protein; EC 4.6.1.2; Nucleotide Metabolism - purine; Membrane protein, integral; Protein kinase, RGC; Guanylyl cyclase; Lyase; RGC group; RGC family Chromosomal Location of Human Ortholog: Xq22 Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; nuclear outer membrane Molecular Function:adenylate cyclase activity; guanylate cyclase activity; receptor activity Biological Process: receptor guanylyl cyclase signaling pathway; regulation of rhodopsin mediated signaling; visual perception
NCBI Summary:	The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]
UniProt Code:	P51841
NCBI GenInfo Identifier:	311033391
NCBI Gene ID:	2986
NCBI Accession:	P51841.2
UniProt Secondary Accession:	P51841,Q9UJF1,
UniProt Related Accession:	P51841
Molecular Weight:	124,850 Da
NCBI Full Name:	Retinal guanylyl cyclase 2
NCBI Synonym Full Names:	guanylate cyclase 2F, retinal
NCBI Official Symbol:	GUCY2F
NCBI Official Synonym Symbols:	CYGF; GC-F; GUC2F; GUC2DL; RETGC-2; ROS-GC2
NCBI Protein Information:	retinal guanylyl cyclase 2
UniProt Protein Name:	Retinal guanylyl cyclase 2
UniProt Synonym Protein Names:	Guanylate cyclase 2F, retinal; Guanylate cyclase F; GC-F; Rod outer segment membrane guanylate cyclase 2; ROS-GC2
Protein Family:	Retinal guanylyl cyclase
UniProt Gene Name:	GUCY2F
UniProt Entry Name:	GUC2F_HUMAN