Cell Biology Antibodies 12

Anti-GUCA2B Antibody (CAB8390)

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SKU:
CAB8390
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GUCA2B Antibody
Antibody SKU:CAB8390
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GUCA2B (NP_009033.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse intestine
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GUCA2B (NP_009033.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGCR AASG LLPG VAVV LLLL LQST QSVY IQYQ GFRV QLES MKKL SDLE AQWA PSPR LQAQ SLLP AVCH HPAL PQDL QPVC ASQE ASSI FKTL RTIA NDDC
Gene ID:2981
Uniprot:Q16661
Cellular Location:Secreted
Calculated MW:12kDa
Observed MW:12kDa
Synonyms:GUCA2B, GCAP-II, UGN
Background:This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.
UniProt Protein Function:GUCA2B: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Belongs to the guanylin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p34-p33

Molecular Function:calcium sensitive guanylate cyclase activator activity

NCBI Summary:This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
UniProt Code:Q16661
NCBI GenInfo Identifier:2495130
NCBI Gene ID:2981
NCBI Accession:Q16661.1
UniProt Secondary Accession:Q16661,Q52LV0,
UniProt Related Accession:Q16661
Molecular Weight:12,069 Da
NCBI Full Name:Guanylate cyclase activator 2B
NCBI Synonym Full Names:guanylate cyclase activator 2B
NCBI Official Symbol:GUCA2B  
NCBI Official Synonym Symbols:UGN; GCAP-II  
NCBI Protein Information:guanylate cyclase activator 2B
UniProt Protein Name:Guanylate cyclase activator 2B
UniProt Synonym Protein Names:Guanylate cyclase C-activating peptide 2Alternative name(s):Guanylate cyclase C-activating peptide II; GCAP-II
Protein Family:Guanylate cyclase activator
UniProt Gene Name:GUCA2B  
UniProt Entry Name:GUC2B_HUMAN
Anti-GUCA2B Polyclonal Antibody (CAB8390)Western blot analysis of extracts of mouse small intestine, using GUCA2B antibody (CAB8390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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