Name: Anti-GUCA1A Antibody (CAB7681)
Brand: Signal Transduction Antibodies 3
SKU: CAB7681
Availability: OutOfStock

Antibody Name:	Anti-GUCA1A Antibody
Antibody SKU:	CAB7681
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human GUCA1A (NP_000400.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human GUCA1A (NP_000400.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGNV MEGK SVEE LSST ECHQ WYKK FMTE CPSG QLTL YEFR QFFG LKNL SPSA SQYV EQMF ETFD FNKD GYID FMEY VAAL SLVL KGKV EQKL RWYF KLYD VDGN GCID RDEL LTII QAIR AINP CSDT TMTA EEFT DTVF SKID VNGD GELS LEEF IEGV QKDQ MLLD TLTR SLDL TRIV RRLQ NGEQ DEEG ADEA AEAA G
Gene ID:	2978
Uniprot:	P43080
Cellular Location:	Lipid-anchor, Membrane
Calculated MW:	22kDa
Observed MW:	Refer to figures

Synonyms:	GUCA1A, C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1
Background:	This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	GUCA1A: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3). COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: plasma membrane Molecular Function:calcium ion binding; calcium sensitive guanylate cyclase activator activity; guanylate cyclase regulator activity Biological Process: positive regulation of guanylate cyclase activity; regulation of rhodopsin mediated signaling Disease: Cone Dystrophy 3
NCBI Summary:	This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:	P43080
NCBI GenInfo Identifier:	46577585
NCBI Gene ID:	2978
NCBI Accession:	P43080.3
UniProt Secondary Accession:	P43080,Q7Z6T1, Q9NU14, B3KWT4,
UniProt Related Accession:	P43080
Molecular Weight:	22,920 Da
NCBI Full Name:	Guanylyl cyclase-activating protein 1
NCBI Synonym Full Names:	guanylate cyclase activator 1A
NCBI Official Symbol:	GUCA1A
NCBI Official Synonym Symbols:	COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
NCBI Protein Information:	guanylyl cyclase-activating protein 1
UniProt Protein Name:	Guanylyl cyclase-activating protein 1
UniProt Synonym Protein Names:	Guanylate cyclase activator 1A
Protein Family:	Guanylyl cyclase-activating protein
UniProt Gene Name:	GUCA1A
UniProt Entry Name:	GUC1A_HUMAN