Cell Biology Antibodies 4

Anti-GTSE1 Antibody (CAB13902)

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SKU:
CAB13902
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GTSE1 Antibody
Antibody SKU:CAB13902
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, U-87MG, HeLa, Mouse spleen, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLAD EKFD FDLS LSSS SANE DDEV FFGP FGHK ERCI AASL ELNN PVPE QPPL PTSE SPFA WSPL AGEK FVEV YKEA HLLA LHIE SSSR NQAA QAAK PEDP RSQG VERF IQES KLKI NLFE KEKE MKKS PTSL KRET YYLS DSPL LGPP VGEP RLLA SSPA LPSS GAQA RLTR APGP PHSA HALP RESC TAHA ASQA ATQR KPGT KLLL PRAA SVRG RSIP GAAE KPKK EIPA SPSR TKIP AEKE SHRD VLPD KPAP GAVN V
Gene ID:51512
Uniprot:Q9NYZ3
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:76kDa
Observed MW:77kDa
Synonyms:GTSE1, B99
Background:The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
UniProt Protein Function:GTSE1: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
UniProt Protein Details:

Protein type:Apoptosis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q13.2-q13.3

Cellular Component: membrane; cytoplasmic microtubule

Molecular Function:protein binding

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; microtubule-based process

NCBI Summary:The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NYZ3
NCBI GenInfo Identifier:317373439
NCBI Gene ID:51512
NCBI Accession:Q9NYZ3.3
UniProt Related Accession:Q9NYZ3
Molecular Weight:77kDa
NCBI Full Name:G2 and S phase-expressed protein 1
NCBI Synonym Full Names:G2 and S-phase expressed 1
NCBI Official Symbol:GTSE1  
NCBI Official Synonym Symbols:B99  
NCBI Protein Information:G2 and S phase-expressed protein 1
UniProt Protein Name:G2 and S phase-expressed protein 1
UniProt Synonym Protein Names:Protein B99 homolog
Protein Family:G2 and S phase-expressed protein
UniProt Gene Name:GTSE1  
UniProt Entry Name:GTSE1_HUMAN
Anti-GTSE1 Antibody (CAB13902)Western blot analysis of extracts of various cell lines, using GTSE1 antibody (CAB13902) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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