Cell Biology Antibodies 17
Anti-GTPBP4 Antibody (CAB4743)
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- SKU:
- CAB4743
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CRFG
- Synonyms:
- NGB
- Synonyms:
- NOG1
- Research Area:
- Cell Biology
Description
| Product Name: | GTPBP4 Rabbit mAb |
| Product Code: | CAB4743 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CRFG, NGB, NOG1 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GTPBP4 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, 293T, Jurkat |
| Immunogen: | A synthesized peptide derived from human GTPBP4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23560 |
| Uniprot: | Q9BZE4 |
| Calculated MW: | 80kDa |
| Observed MW: | 74KDa |
| UniProt Protein Function: | GTPBP4: Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the GTP1/OBG family. NOG subfamily. |
| UniProt Protein Details: | Protein type:Nucleolus; RNA-binding; Ribosomal Chromosomal Location of Human Ortholog: 10p15-p14 Cellular Component: Golgi apparatus; nuclear membrane; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: osteoblast differentiation; negative regulation of cell proliferation; protein stabilization; metabolic process; negative regulation of DNA replication; ribosome biogenesis and assembly; negative regulation of protein ubiquitination; regulation of cyclin-dependent protein kinase activity; negative regulation of cell-cell adhesion; negative regulation of cell migration; negative regulation of collagen binding |
| NCBI Summary: | GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZE4 |
| NCBI GenInfo Identifier: | 17368711 |
| NCBI Gene ID: | 23560 |
| NCBI Accession: | Q9BZE4.3 |
| UniProt Related Accession: | Q9BZE4 |
| Molecular Weight: | |
| NCBI Full Name: | Nucleolar GTP-binding protein 1 |
| NCBI Synonym Full Names: | GTP binding protein 4 |
| NCBI Official Symbol: | GTPBP4 |
| NCBI Official Synonym Symbols: | NGB; CRFG; NOG1 |
| NCBI Protein Information: | nucleolar GTP-binding protein 1 |
| UniProt Protein Name: | Nucleolar GTP-binding protein 1 |
| UniProt Synonym Protein Names: | Chronic renal failure gene protein; GTP-binding protein NGB |
| Protein Family: | Noggin |
| UniProt Gene Name: | GTPBP4 |
| UniProt Entry Name: | NOG1_HUMAN |
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