Epigenetics & Nuclear Signaling Antibodies 4

Anti-GTF2I Antibody (CAB7898)

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SKU:
CAB7898
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-GTF2I Antibody
Antibody SKU:CAB7898
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human GTF2I
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, Mouse brain
Immunogen:A synthetic peptide of human GTF2I
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2969
Uniprot:P78347
Cellular Location:Cytoplasm, Nucleus
Calculated MW:30kDa/107kDa/110kDa/112kDa
Observed MW:132kDa
Synonyms:GTF2I, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
Background:This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
UniProt Protein Function:GTF2I: a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described.
UniProt Protein Details:

Protein type:DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus

Molecular Function:DNA binding; protein binding

Biological Process: negative regulation of angiogenesis; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

Disease: Williams-beuren Syndrome

NCBI Summary:This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]
UniProt Code:P78347
NCBI GenInfo Identifier:17865459
NCBI Gene ID:2969
NCBI Accession:P78347.2
UniProt Secondary Accession:P78347,O14743, O15359, O43546, O43588, O43589, Q75M85 Q75M86, Q75M87, Q75M88, Q86U51, Q9BSZ4,
UniProt Related Accession:P78347
Molecular Weight:112kDa
NCBI Full Name:General transcription factor II-I
NCBI Synonym Full Names:general transcription factor IIi
NCBI Official Symbol:GTF2I  
NCBI Official Synonym Symbols:WBS; DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; GTFII-I  
NCBI Protein Information:general transcription factor II-I
UniProt Protein Name:General transcription factor II-I
UniProt Synonym Protein Names:Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region 6 protein
Protein Family:General transcription factor
UniProt Gene Name:GTF2I  
Anti-GTF2I Antibody (CAB7898)Immunohistochemistry of paraffin-embedded rat kidney using GTF2I antibody (CAB7898) (40x lens).
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