Anti-GTF2I Antibody (CAB0542)
- SKU:
- CAB0542
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GTF2I
- Synonyms:
- BAP135
- Synonyms:
- BTKAP1
- Synonyms:
- DIWS
- Synonyms:
- GTFII-I
- Synonyms:
- IB291
- Synonyms:
- SPIN
- Synonyms:
- TFII-I
- Synonyms:
- WBS
- Synonyms:
- WBSCR6
- Synonyms:
- general transcription factor IIi
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | GTF2I Rabbit mAb |
| Product Code: | CAB0542 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GTF2I, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6, general transcription factor IIi |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GTF2I. |
| Applications: | IHC |
| Recommended Dilutions: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human GTF2I. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2969 |
| Uniprot: | P78347 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 135kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | GTF2I: a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding Biological Process: negative regulation of angiogenesis; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter Disease: Williams-beuren Syndrome |
| NCBI Summary: | This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P78347 |
| NCBI GenInfo Identifier: | 17865459 |
| NCBI Gene ID: | 2969 |
| NCBI Accession: | P78347.2 |
| UniProt Secondary Accession: | P78347,O14743, O15359, O43546, O43588, O43589, Q75M85 Q75M86, Q75M87, Q75M88, Q86U51, Q9BSZ4, |
| UniProt Related Accession: | P78347 |
| Molecular Weight: | 112kDa |
| NCBI Full Name: | General transcription factor II-I |
| NCBI Synonym Full Names: | general transcription factor IIi |
| NCBI Official Symbol: | GTF2I |
| NCBI Official Synonym Symbols: | WBS; DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; GTFII-I |
| NCBI Protein Information: | general transcription factor II-I |
| UniProt Protein Name: | General transcription factor II-I |
| UniProt Synonym Protein Names: | Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region 6 protein |
| Protein Family: | General transcription factor |
| UniProt Gene Name: | GTF2I |
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