Epigenetics & Nuclear Signaling Antibodies 4
Anti-GTF2H4 Antibody (CAB8425)
- SKU:
- CAB8425
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GTF2H4 Antibody |
| Antibody SKU: | CAB8425 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GTF2H4 (NP_001508.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HL-60, HeLa, Mouse brain, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GTF2H4 (NP_001508.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEST PSRG LNRV HLQC RNLQ EFLG GLSP GVLD RLYG HPAT CLAV FREL PSLA KNWV MRML FLEQ PLPQ AAVA LWVK KEFS KAQE ESTG LLSG LRIW HTQL LPGG LQGL ILNP IFRQ NLRI ALLG GGKA WSDD TSQL GPDK HARD VPSL DKYA EERW EVVL HFMV GSPS AAVS QDLA QLLS QAGL MKST EPGE PPCI TSAG FQFL LLDT PAQL WYFM LQYL QTAQ SRGM DLVE ILSF LFQL SFST LGKD YSVE GMSD SLLN FLQH LREF GLVF QRKR KSRR YYPT RLAI NLSS GVSG AGGT |
| Gene ID: | 2968 |
| Uniprot: | Q92759 |
| Cellular Location: | Nucleus |
| Calculated MW: | 24kDa/52kDa |
| Observed MW: | 52kDa |
| Synonyms: | GTF2H4, P52, TFB2, TFIIH |
| Background: |
| UniProt Protein Function: | GTF2H4: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Belongs to the TFB2 family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Transcription factor Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: holo TFIIH complex; nucleoplasm Molecular Function:DNA-dependent ATPase activity; double-stranded DNA binding; protein binding; protein kinase activity; RNA polymerase subunit kinase activity; transcription factor activity Biological Process: DNA repair; mRNA capping; nucleotide-excision repair; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
| UniProt Code: | Q92759 |
| NCBI GenInfo Identifier: | 17380328 |
| NCBI Gene ID: | 2968 |
| NCBI Accession: | Q92759.1 |
| UniProt Secondary Accession: | Q92759,Q76KU4, B4DTJ5, |
| UniProt Related Accession: | Q92759 |
| Molecular Weight: | 24,630 Da |
| NCBI Full Name: | General transcription factor IIH subunit 4 |
| NCBI Synonym Full Names: | general transcription factor IIH subunit 4 |
| NCBI Official Symbol: | GTF2H4 |
| NCBI Official Synonym Symbols: | P52; TFB2; TFIIH |
| NCBI Protein Information: | general transcription factor IIH subunit 4 |
| UniProt Protein Name: | General transcription factor IIH subunit 4 |
| UniProt Synonym Protein Names: | Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit |
| Protein Family: | General transcription factor |
| UniProt Gene Name: | GTF2H4 |
| UniProt Entry Name: | TF2H4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GTF2H4 antibody (CAB8425) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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