| UniProt Protein Function: | GTF2H3: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB. Belongs to the TFB4 family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Transcription factor Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: nucleoplasm; holo TFIIH complex Molecular Function:RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; translation factor activity, nucleic acid binding; metal ion binding; damaged DNA binding; protein N-terminus binding; transcription factor activity; protein kinase activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; translation; viral reproduction; positive regulation of viral transcription; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; DNA repair; protein amino acid phosphorylation; regulation of gene expression, epigenetic; mRNA capping; regulation of transcription, DNA-dependent; negative regulation of gene expression, epigenetic; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression; nucleotide-excision repair, DNA damage removal; transcription initiation from RNA polymerase I promoter |
| NCBI Summary: | This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q13889 |
| NCBI GenInfo Identifier: | 50403772 |
| NCBI Gene ID: | 2967 |
| NCBI Accession: | Q13889.2 |
| UniProt Secondary Accession: | Q13889,Q7L0G0, Q96AT7, B2R819, B4DNZ6, |
| UniProt Related Accession: | Q13889 |
| Molecular Weight: | 308 |
| NCBI Full Name: | General transcription factor IIH subunit 3 |
| NCBI Synonym Full Names: | general transcription factor IIH, polypeptide 3, 34kDa |
| NCBI Official Symbol: | GTF2H3 |
| NCBI Official Synonym Symbols: | P34; BTF2; TFB4; TFIIH |
| NCBI Protein Information: | general transcription factor IIH subunit 3; basic transcription factor 2 34 kDa subunit; TFIIH basal transcription factor complex p34 subunit |
| UniProt Protein Name: | General transcription factor IIH subunit 3 |
| UniProt Synonym Protein Names: | Basic transcription factor 2 34 kDa subunit; BTF2 p34; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunit |
| Protein Family: | General transcription factor |
| UniProt Gene Name: | GTF2H3 |
| UniProt Entry Name: | TF2H3_HUMAN |
