| UniProt Protein Function: | GTF2F1: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the TFIIF alpha subunit family. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Transcription initiation complex; ATYPICAL group; GTF2F1 family Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleoplasm; transcription factor TFIIF complex; cell junction; nucleus Molecular Function:protein binding; DNA binding; phosphatase activator activity; transcription coactivator activity; transcription factor binding; catalytic activity Biological Process: positive regulation of catalytic activity; transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; transcription initiation from RNA polymerase II promoter; mRNA capping; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; RNA splicing; response to virus; RNA elongation from RNA polymerase II promoter; gene expression |
| UniProt Code: | P35269 |
| NCBI GenInfo Identifier: | 46397744 |
| NCBI Gene ID: | 2962 |
| NCBI Accession: | P35269.2 |
| UniProt Secondary Accession: | P35269,Q9BWN0, B2RCS0, |
| UniProt Related Accession: | P35269 |
| Molecular Weight: | 517 |
| NCBI Full Name: | General transcription factor IIF subunit 1 |
| NCBI Synonym Full Names: | general transcription factor IIF, polypeptide 1, 74kDa |
| NCBI Official Symbol: | GTF2F1 |
| NCBI Official Synonym Symbols: | BTF4; RAP74; TF2F1; TFIIF |
| NCBI Protein Information: | general transcription factor IIF subunit 1; TFIIF-alpha; transcription initiation factor RAP74; general transcription factor IIF 74 kDa subunit; transcription initiation factor IIF subunit alpha |
| UniProt Protein Name: | General transcription factor IIF subunit 1 |
| UniProt Synonym Protein Names: | General transcription factor IIF 74 kDa subunit; Transcription initiation factor IIF subunit alpha; TFIIF-alpha; Transcription initiation factor RAP74 |
| Protein Family: | General transcription factor |
| UniProt Gene Name: | GTF2F1 |
| UniProt Entry Name: | T2FA_HUMAN |
