Cell Biology Antibodies 9
Anti-GSTK1 Antibody (CAB5226)
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- SKU:
- CAB5226
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GSTK1 Antibody |
| Antibody SKU: | CAB5226 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human GSTK1 (NP_057001.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, K-562, HeLa, HepG2, SW620, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human GSTK1 (NP_057001.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGPL PRTV ELFY DVLS PYSW LGFE ILCR YQNI WNIN LQLR PSLI TGIM KDSG NKPP GLLP RKGL YMAN DLKL LRHH LQIP IHFP KDFL SVML EKGS LSAM RFLT AVNL EHPE MLEK ASRE LWMR VWSR NEDI TEPQ SILA AAEK AGMS AEQA QGLL EKIA TPKV KNQL KETT EAAC RYGA FGLP ITVA HVDG QTHM LFGS DRME LLAH LLGE KWMG PIPP AVNA RL |
| Gene ID: | 373156 |
| Uniprot: | Q9Y2Q3 |
| Cellular Location: | Peroxisome |
| Calculated MW: | 20kDa/24kDa/25kDa/31kDa |
| Observed MW: | 25kDa |
| Synonyms: | GSTK1, GST, GST 13-13, GST13, GST13-13, GSTK1-1, hGSTK1 |
| Background: | This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GSTK1: Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Belongs to the GST superfamily. Kappa family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 7q34 Cellular Component: membrane; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrial inner membrane; peroxisome; intracellular Molecular Function:glutathione transferase activity; protein disulfide oxidoreductase activity; glutathione peroxidase activity; receptor binding Biological Process: glutathione metabolic process; epithelial cell differentiation |
| NCBI Summary: | This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9Y2Q3 |
| NCBI GenInfo Identifier: | 12643338 |
| NCBI Gene ID: | 373156 |
| NCBI Accession: | Q9Y2Q3.3 |
| UniProt Secondary Accession: | Q9Y2Q3,Q6P4H0, Q7Z520, Q9P1S4, B4DIH1, B4DSY2, |
| UniProt Related Accession: | Q9Y2Q3 |
| Molecular Weight: | 226 |
| NCBI Full Name: | Glutathione S-transferase kappa 1 |
| NCBI Synonym Full Names: | glutathione S-transferase kappa 1 |
| NCBI Official Symbol: | GSTK1 |
| NCBI Official Synonym Symbols: | GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13 |
| NCBI Protein Information: | glutathione S-transferase kappa 1; GST class-kappa; glutathione S-transferase k1; glutathione S-transferase subunit 13 homolog |
| UniProt Protein Name: | Glutathione S-transferase kappa 1 |
| UniProt Synonym Protein Names: | GST 13-13; GST class-kappa; GSTK1-1; hGSTK1; Glutathione S-transferase subunit 13 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTK1 |
| UniProt Entry Name: | GSTK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GSTK1 antibody (CAB5226) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using GSTK1 Rabbit pAb (CAB5226) at dilution of 1:25 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using GSTK1 Rabbit pAb (CAB5226) at dilution of 1:25 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using GSTK1 Rabbit pAb (CAB5226) at dilution of 1:25 (40x lens). |
 | Immunofluorescence analysis of Hela cells using GSTK1 antibody (CAB5226) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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