Cell Biology Antibodies 13
Anti-GSTA3 Antibody (CAB17491)
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- SKU:
- CAB17491
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GSTA3 Antibody |
| Antibody SKU: | CAB17491 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA3 (NP_000838.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, 293T, Mouse lung, Mouse liver, Mouse kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA3 (NP_000838.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGK PKLH YFNG RGRM EPIR WLLA AAGV EFEE KFIG SAED LGKL RNDG SLMF QQVP MVEI DGMK LVQT RAIL NYIA SKYN LYGK DIKE RALI DMYT EGMA DLNE MILL LPLC RPEE KDAK IALI KEKT KSRY FPAF EKVL QSHG QDYL VGNK LSRA DISL VELL YYVE ELDS SLIS NFPL LKAL KTRI SNLP TVKK FLQP GSPR KPPA DAKA LEEA RKIF RF |
| Gene ID: | 2940 |
| Uniprot: | Q16772 |
| Cellular Location: | |
| Calculated MW: | 25kDa |
| Observed MW: | 25kDa |
 | Western blot - GSTA3 Polyclonal Antibody (CAB17491) |
| Synonyms: | GSTA3, GSTA3-3, GTA3 |
| Background: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GSTA3: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Belongs to the GST superfamily. Alpha family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Transferase Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity Biological Process: glutathione metabolic process |
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16772 |
| NCBI GenInfo Identifier: | 21264437 |
| NCBI Gene ID: | 2940 |
| NCBI Accession: | Q16772.3 |
| UniProt Secondary Accession: | Q16772,O43468, Q068V6, Q8WWA8, Q9H415, |
| UniProt Related Accession: | Q16772 |
| Molecular Weight: | 25,302 Da |
| NCBI Full Name: | Glutathione S-transferase A3 |
| NCBI Synonym Full Names: | glutathione S-transferase alpha 3 |
| NCBI Official Symbol: | GSTA3 |
| NCBI Official Synonym Symbols: | GTA3; GSTA3-3 |
| NCBI Protein Information: | glutathione S-transferase A3 |
| UniProt Protein Name: | Glutathione S-transferase A3 |
| UniProt Synonym Protein Names: | GST class-alpha member 3; Glutathione S-transferase A3-3 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTA3 |
| UniProt Entry Name: | GSTA3_HUMAN |
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