Cell Biology Antibodies 18

Anti-GSTA1 Antibody (CAB18266)

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SKU:
CAB18266
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GSTA1 Antibody
Antibody SKU:CAB18266
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse kidney, Mouse stomach, Rat liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2938
Uniprot:P08263
Cellular Location:Cytoplasm
Calculated MW:25kDa
Observed MW:24kDa
Anti-GSTA1 Antibody (CAB18266)Western blot - GSTA1 Rabbit pAb (CAB18266)
Synonyms:GSTA1, GST-epsilon, GST2, GSTA1-1, GTH1
Background:This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:GSTA1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family.
UniProt Protein Details:

Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Transferase

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: cytosol

Molecular Function:glutathione transferase activity

Biological Process: glutathione metabolic process; epithelial cell differentiation; metabolic process; xenobiotic metabolic process

NCBI Summary:Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
UniProt Code:P08263
NCBI GenInfo Identifier:121730
NCBI Gene ID:2938
NCBI Accession:P08263.3
UniProt Secondary Accession:P08263,Q14750, Q5GHF8, Q5SZC1,
UniProt Related Accession:P08263
Molecular Weight:222
NCBI Full Name:Glutathione S-transferase A1
NCBI Synonym Full Names:glutathione S-transferase alpha 1
NCBI Official Symbol:GSTA1  
NCBI Official Synonym Symbols:GST2; GTH1; GSTA1-1  
NCBI Protein Information:glutathione S-transferase A1; GST-epsilon; GST HA subunit 1; GST, class alpha, 1; GST class-alpha member 1; glutathione S-transferase 2; glutathione S-aryltransferase A1; glutathione S-alkyltransferase A1; S-(hydroxyalkyl)glutathione lyase A1; glutathione S-transferase Ha subunit 1
UniProt Protein Name:Glutathione S-transferase A1
UniProt Synonym Protein Names:GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1Glutathione S-transferase A1, N-terminally processed
Protein Family:Glutathione S-transferase
UniProt Gene Name:GSTA1  
UniProt Entry Name:GSTA1_HUMAN
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