Cell Biology Antibodies 14
Anti-GSN Antibody (CAB16869)
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- SKU:
- CAB16869
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GSN Antibody |
| Antibody SKU: | CAB16869 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 543-782 of human GSN (NP_000168.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, SW480, LO2, BT-474, NIH/3T3, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 543-782 of human GSN (NP_000168.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PMII YKGG TSRE GGQT APAS TRLF QVRA NSAG ATRA VEVL PKAG ALNS NDAF VLKT PSAA YLWV GTGA SEAE KTGA QELL RVLR AQPV QVAE GSEP DGFW EALG GKAA YRTS PRLK DKKM DAHP PRLF ACSN KIGR FVIE EVPG ELMQ EDLA TDDV MLLD TWDQ VFVW VGKD SQEE EKTE ALTS AKRY IETD PANR DRRT PITV VKQG FEPP SFVG WFLG WDDD YWSV DPLD RAMA ELAA |
| Gene ID: | 2934 |
| Uniprot: | P06396 |
| Cellular Location: | Cytoplasm, Secreted, cytoskeleton |
| Calculated MW: | 80kDa/81kDa/85kDa |
| Observed MW: | 80kDa |
 | Western blot - GSN Rabbit pAb (CAB16869) |
| Synonyms: | GSN, ADF, AGEL, gelsolin |
| Background: | The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| UniProt Protein Function: | Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 9q33 Cellular Component: ruffle; focal adhesion; protein complex; perinuclear region of cytoplasm; lamellipodium; extracellular region; cytosol; actin cytoskeleton Molecular Function:protein binding; calcium ion binding; actin binding Biological Process: regulation of cell adhesion; actin filament severing; phosphoinositide-mediated signaling; apoptosis; actin nucleation; vesicle-mediated transport; response to ethanol; actin filament polymerization; tissue regeneration; response to folic acid; oligodendrocyte development; barbed-end actin filament capping; cell structure disassembly during apoptosis; aging Disease: Amyloidosis, Finnish Type |
| NCBI Summary: | The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P06396 |
| NCBI GenInfo Identifier: | 121116 |
| NCBI Gene ID: | 2934 |
| NCBI Accession: | P06396.1 |
| UniProt Secondary Accession: | P06396,Q5T0I2, Q8WVV7, A2A418, A8MUD1, A8MYN7, B7Z373 B7Z5V1, F5H1A8, |
| UniProt Related Accession: | P06396 |
| Molecular Weight: | 782 |
| NCBI Full Name: | Gelsolin |
| NCBI Synonym Full Names: | gelsolin |
| NCBI Official Symbol: | GSN |
| NCBI Official Synonym Symbols: | ADF; AGEL |
| NCBI Protein Information: | gelsolin; brevin; actin-depolymerizing factor |
| UniProt Protein Name: | Gelsolin |
| UniProt Synonym Protein Names: | AGEL; Actin-depolymerizing factor; ADF; Brevin |
| Protein Family: | Gelsolin |
| UniProt Gene Name: | GSN |
| UniProt Entry Name: | GELS_HUMAN |
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