Cell Death Antibodies 2

Anti-GSDMB Antibody (CAB7474)

(No reviews yet) Write a Review
SKU:
CAB7474
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-GSDMB Antibody
Antibody SKU:CAB7474
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GSDMB (NP_001159431.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HT-29, Mouse intestine, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GSDMB (NP_001159431.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFSV FEEI TRIV VKEM DAGG DMIA VRSL VDAD RFRC FHLV GEKR TFFG CRHY TTGL TLMD ILDT DGDK WLDE LDSG LQGQ KAEF QILD NVDS TGEL IVRL PKEI TISG SFQG FHHQ KIKI SENR ISQQ YLAT LENR KLKR ELPF SFRS INTR ENLY LVTE TLET VKEE TLKS DRQY KFWS QISQ GHLS YKHK GQRE VTIP PNRV LSYR VKQL VFPN KETM NIHF RGKT KSFP EGKS LGSE DSRN MKEK LEDM ESVL KDLT EEKR KDVL NS
Gene ID:55876
Uniprot:Q8TAX9
Cellular Location:Cytoplasm
Calculated MW:18kDa/45kDa/46kDa/47kDa
Observed MW:47kDa
Synonyms:GSDMB, GSDML, PP4052, PRO2521
Background:This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
UniProt Protein Function:GSDML: May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells. Belongs to the gasdermin family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm

NCBI Summary:This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009]
UniProt Code:Q8TAX9
NCBI GenInfo Identifier:182647404
NCBI Gene ID:55876
NCBI Accession:Q8TAX9.2
UniProt Secondary Accession:Q8TAX9,Q7Z377, Q8WY76, Q9NX71, Q9P163, B4DKK7,
UniProt Related Accession:Q8TAX9
Molecular Weight:411
NCBI Full Name:Gasdermin-B
NCBI Synonym Full Names:gasdermin B
NCBI Official Symbol:GSDMB  
NCBI Official Synonym Symbols:GSDML; PP4052; PRO2521  
NCBI Protein Information:gasdermin-B; gasdermin-like protein
UniProt Protein Name:Gasdermin-B
UniProt Synonym Protein Names:Gasdermin-like protein
Protein Family:Gasdermin
UniProt Gene Name:GSDMB  
UniProt Entry Name:GSDMB_HUMAN
Anti-GSDMB Antibody (CAB7474)Western blot analysis of extracts of various cell lines, using GSDMB antibody (CAB7474) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products