Immunology Antibodies 2

Anti-GRO alpha Antibody (CAB5802)

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SKU:
CAB5802
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-GRO alpha Antibody
Antibody SKU:CAB5802
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human GRO alpha (NP_001502.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:DU145, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human GRO alpha (NP_001502.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MARA ALSA APSN PRLL RVAL LLLL LVAA GRRA AGAS VATE LRCQ CLQT LQGI HPKN IQSV NVKS PGPH CAQT EVIA TLKN GRKA CLNP ASPI VKKI IEKM LNSD KSN
Gene ID:2919
Uniprot:P09341
Cellular Location:Secreted
Calculated MW:11kDa
Observed MW:11kDa
Synonyms:CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1, GRO alpha
Background:This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.
UniProt Protein Function:CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function:growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding

Biological Process: positive regulation of catalytic activity; G-protein coupled receptor protein signaling pathway; cell proliferation; nervous system development; negative regulation of cell proliferation; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction

NCBI Summary:This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
UniProt Code:P09341
NCBI GenInfo Identifier:121622
NCBI Gene ID:2919
NCBI Accession:P09341.1
UniProt Secondary Accession:P09341,Q9UCR7,
UniProt Related Accession:P09341
Molecular Weight:
NCBI Full Name:Growth-regulated alpha protein
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
NCBI Official Symbol:CXCL1  
NCBI Official Synonym Symbols:FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a  
NCBI Protein Information:growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha)
UniProt Protein Name:Growth-regulated alpha protein
UniProt Synonym Protein Names:C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3
Protein Family:Growth-regulated alpha protein
UniProt Gene Name:CXCL1  
UniProt Entry Name:GROA_HUMAN
Anti-GRO alpha Antibody (CAB5802)Western blot analysis of extracts of DU145 cells, using GRO alpha antibody (CAB5802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-GRO alpha Antibody (CAB5802)Western blot analysis of extracts of Jurkat cells, using GRO alpha antibody (CAB5802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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