Signal Transduction Antibodies 2

Anti-GRM8 Antibody (CAB2964)

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SKU:
CAB2964
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GRM8 Antibody
Antibody SKU:CAB2964
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human GRM8
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, 22Rv1, HepG2, HeLa
Immunogen:A synthetic peptide of human GRM8
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2918
Uniprot:O00222
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:55kDa/101kDa
Observed MW:120kDa
Synonyms:GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8
Background:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniProt Protein Function:mGluR8: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31.3-q32.1

Cellular Component: integral to plasma membrane; plasma membrane; presynaptic membrane

Molecular Function:G-protein coupled receptor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity

Biological Process: metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; regulation of synaptic transmission, glutamatergic; visual perception

NCBI Summary:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O00222
NCBI GenInfo Identifier:12644040
NCBI Gene ID:2918
NCBI Accession:O00222.2
UniProt Secondary Accession:O00222,O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165 A4D0Y3, B0FZ74, B0M0L0,
UniProt Related Accession:O00222
Molecular Weight:55,948 Da
NCBI Full Name:Metabotropic glutamate receptor 8
NCBI Synonym Full Names:glutamate metabotropic receptor 8
NCBI Official Symbol:GRM8  
NCBI Official Synonym Symbols:GLUR8; mGlu8; GPRC1H; MGLUR8  
NCBI Protein Information:metabotropic glutamate receptor 8
UniProt Protein Name:Metabotropic glutamate receptor 8
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM8  
UniProt Entry Name:GRM8_HUMAN
Anti-GRM8 Antibody (CAB2964)Western blot analysis of extracts of various cell lines, using GRM8 antibody (CAB2964) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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