Cell Biology Antibodies 14

Anti-GRM6 Antibody (CAB16867)

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SKU:
CAB16867
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GRM6 Antibody
Antibody SKU:CAB16867
Antibody Size:20uL, 50 uL
Application:IF
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-580 of human GRM6 (NP_000834.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-580 of human GRM6 (NP_000834.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GSAS SGGY QAVG QWAE TLRL DVEA LQWS GDPH EVPS SLCS LPCG PGER KKMV KGVP CCWH CEAC DGYR FQVD EFTC EACP GDMR PTPN HTGC RPTP VVRL S
Gene ID:2916
Uniprot:O15303
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6
Background:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
UniProt Protein Function:mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: endoplasmic reticulum membrane; Golgi membrane; integral to plasma membrane; plasma membrane; presynaptic membrane

Molecular Function:G-protein coupled receptor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity; protein binding; protein homodimerization activity

Biological Process: detection of light stimulus involved in visual perception; detection of visible light; metabotropic glutamate receptor signaling pathway; regulation of synaptic transmission, glutamatergic

Disease: Night Blindness, Congenital Stationary, Type 1b

NCBI Summary:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
UniProt Code:O15303
NCBI GenInfo Identifier:239938639
NCBI Gene ID:2916
NCBI Accession:O15303.2
UniProt Related Accession:O15303
Molecular Weight:95,468 Da
NCBI Full Name:Metabotropic glutamate receptor 6
NCBI Synonym Full Names:glutamate metabotropic receptor 6
NCBI Official Symbol:GRM6  
NCBI Official Synonym Symbols:mGlu6; CSNB1B; GPRC1F; MGLUR6  
NCBI Protein Information:metabotropic glutamate receptor 6
UniProt Protein Name:Metabotropic glutamate receptor 6
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM6  
UniProt Entry Name:GRM6_HUMAN
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