Cell Biology Antibodies 12
Anti-GRM5 Antibody (CAB9819)
(No reviews yet)
Write a Review
- SKU:
- CAB9819
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GRM5 Antibody |
| Antibody SKU: | CAB9819 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GSSG ETLR YKDR RLAQ HKSE IECF TPKG SMGN GGRA TMSS SNGK SVTW AQNE KSSR GQHL WQRL SIHI NKKE NPNQ TAVI KPFP KSTE SRGL GAGA GAGG SAGG VGAT GGAG CAGA GPGG PESP DAGP KALY DVAE AEEH FPAP ARPR SPSP ISTL SHRA GSAS RTDD DVPS LHSE PVAR SSSS QGSL MEQI SSVV TRFT A |
| Gene ID: | 2915 |
| Uniprot: | P41594 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 105kDa/128kDa/132kDa |
| Observed MW: | 132kDa |
| Synonyms: | GRM5, GPRC1E, MGLUR5, PPP1R86, mGlu5 |
| Background: | This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q14.3 Cellular Component: integral to plasma membrane; plasma membrane; postsynaptic density Molecular Function:G-protein coupled receptor activity; glutamate receptor activity Biological Process: cognition; metabotropic glutamate receptor signaling pathway; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; regulation of synaptic transmission, glutamatergic; synaptic transmission |
| NCBI Summary: | This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | P41594 |
| NCBI GenInfo Identifier: | 1709020 |
| NCBI Gene ID: | 2915 |
| NCBI Accession: | P41594.2 |
| UniProt Secondary Accession: | P41594,Q6J164, |
| UniProt Related Accession: | P41594 |
| Molecular Weight: | 105,432 Da |
| NCBI Full Name: | Metabotropic glutamate receptor 5 |
| NCBI Synonym Full Names: | glutamate metabotropic receptor 5 |
| NCBI Official Symbol: | GRM5 |
| NCBI Official Synonym Symbols: | mGlu5; GPRC1E; MGLUR5; PPP1R86 |
| NCBI Protein Information: | metabotropic glutamate receptor 5 |
| UniProt Protein Name: | Metabotropic glutamate receptor 5 |
| Protein Family: | Metabotropic glutamate receptor |
| UniProt Gene Name: | GRM5 |
| UniProt Entry Name: | GRM5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRM5 antibody (CAB9819) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
