Cell Biology Antibodies 17

Anti-GRM5 Antibody (CAB3758)

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SKU:
CAB3758
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GRM5 Antibody
Antibody SKU:CAB3758
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GRM5
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain
Immunogen:A synthesized peptide derived from human GRM5
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2915
Uniprot:P41594
Cellular Location:
Calculated MW:132kDa
Observed MW:150kDa
Synonyms:GPRC1E, MGLUR5, PPP1R86, mGlu5
Background:This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Protein Function:mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: integral to plasma membrane; plasma membrane; postsynaptic density

Molecular Function:G-protein coupled receptor activity; glutamate receptor activity

Biological Process: cognition; metabotropic glutamate receptor signaling pathway; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; regulation of synaptic transmission, glutamatergic; synaptic transmission

NCBI Summary:This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:P41594
NCBI GenInfo Identifier:1709020
NCBI Gene ID:2915
NCBI Accession:P41594.2
UniProt Secondary Accession:P41594,Q6J164,
UniProt Related Accession:P41594
Molecular Weight:105,432 Da
NCBI Full Name:Metabotropic glutamate receptor 5
NCBI Synonym Full Names:glutamate metabotropic receptor 5
NCBI Official Symbol:GRM5  
NCBI Official Synonym Symbols:mGlu5; GPRC1E; MGLUR5; PPP1R86  
NCBI Protein Information:metabotropic glutamate receptor 5
UniProt Protein Name:Metabotropic glutamate receptor 5
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM5  
UniProt Entry Name:GRM5_HUMAN
Anti-GRM5 Antibody (CAB3758)Western blot - GRM5 Rabbit mAb (CAB3758)
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