Cell Biology Antibodies 9
Anti-GRIP1 Antibody (CAB5747)
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- SKU:
- CAB5747
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GRIP1 Antibody |
| Antibody SKU: | CAB5747 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GRIP1 (NP_001171545.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GRIP1 (NP_001171545.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MIAV SFKC RCQI LRRL TKDE SPYT KSAS QTKP PDGA LAVR RQSI PEEF KGST VVEL MKKE GTTL GLTV SGGI DKDG KPRV SNLR QGGI AARS DQLD VGDY IKAV NGIN LAKF RHDE IISL LKNV GERV VLEV EYEL PPVS VQGS SVIF RTVE VTLH KEGN TFGF VIRG GAHD DRNK SRPV VITC VRPG GP |
| Gene ID: | 23426 |
| Uniprot: | Q9Y3R0 |
| Cellular Location: | Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, postsynaptic cell membrane, synapse |
| Calculated MW: | 116kDa/120kDa/122kDa |
| Observed MW: | 131kDa |
| Synonyms: | GRIP1, GRIP |
| Background: | This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | GRIP1: a scaffold protein for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific locations in neurons. Interacts with EphA7, EphB2, KIF5A, -B, -C, GluR2, -3, GRIPAP1, liprin A1, PPFIA4, FRAS1, and PTPRF. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 12q14.3 Cellular Component: postsynaptic membrane; recycling endosome; neuron projection; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; plasma membrane; cytosol; cell junction; lipid raft Molecular Function:protein C-terminus binding; protein binding; receptor signaling complex scaffold activity; androgen receptor binding; transcription coactivator activity; beta-catenin binding; glucocorticoid receptor binding Biological Process: synaptic transmission; protein localization; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; dendrite development Disease: Fraser Syndrome |
| NCBI Summary: | This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9Y3R0 |
| NCBI GenInfo Identifier: | 313104231 |
| NCBI Gene ID: | 23426 |
| NCBI Accession: | Q9Y3R0.3 |
| UniProt Secondary Accession: | Q9Y3R0,Q1RLM0, C9JT59, |
| UniProt Related Accession: | Q9Y3R0 |
| Molecular Weight: | 1128 |
| NCBI Full Name: | Glutamate receptor-interacting protein 1 |
| NCBI Synonym Full Names: | glutamate receptor interacting protein 1 |
| NCBI Official Symbol: | GRIP1 |
| NCBI Official Synonym Symbols: | GRIP |
| NCBI Protein Information: | glutamate receptor-interacting protein 1 |
| UniProt Protein Name: | Glutamate receptor-interacting protein 1 |
| Protein Family: | GRIP1-associated protein |
| UniProt Gene Name: | GRIP1 |
| UniProt Entry Name: | GRIP1_HUMAN |
 | Western blot analysis of extracts of 293T cells, using GRIP1 Antibody (CAB5747) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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