Cell Biology Antibodies 16
Anti-GRIK3 Antibody (CAB10701)
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- SKU:
- CAB10701
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GRIK3 Antibody |
| Antibody SKU: | CAB10701 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GRIK3 (NP_000822.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GRIK3 (NP_000822.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPHV IRIG GIFE YADG PNAQ VMNA EEHA FRFS ANII NRNR TLLP NTTL TYDI QRIH FHDS FEAT KKAC DQLA LGVV AIFG PSQG SCTN AVQS ICNA LEVP HIQL RWKH HPLD NKDT FYVN LYPD YASL SHAI LDLV QYLK WRSA TVVY DDST GLIR LQEL IMAP SRYN IRLK IRQL PIDS DDSR PLLK EMKR GREF RIIF DCSH TMAA Q |
| Gene ID: | 2899 |
| Uniprot: | Q13003 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 98kDa/104kDa |
| Observed MW: | Refer to figures |
| Synonyms: | GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, kainate 3 |
| Background: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. |
| UniProt Protein Function: | GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: axon; dendrite; dendrite cytoplasm; integral to plasma membrane; perikaryon; plasma membrane; terminal button Molecular Function:adenylate cyclase inhibiting metabotropic glutamate receptor activity; G-protein-coupled receptor binding; glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity Biological Process: glutamate signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; regulation of membrane potential |
| NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13003 |
| NCBI GenInfo Identifier: | 212276502 |
| NCBI Gene ID: | 2899 |
| NCBI Accession: | Q13003.3 |
| UniProt Secondary Accession: | Q13003,Q13004, Q16136, A9Z1Z8, B1AMS6, |
| UniProt Related Accession: | Q13003 |
| Molecular Weight: | 98,727 Da |
| NCBI Full Name: | Glutamate receptor ionotropic, kainate 3 |
| NCBI Synonym Full Names: | glutamate ionotropic receptor kainate type subunit 3 |
| NCBI Official Symbol: | GRIK3 |
| NCBI Official Synonym Symbols: | EAA5; GLR7; GLUR7; GluK3; GluR7a |
| NCBI Protein Information: | glutamate receptor ionotropic, kainate 3 |
| UniProt Protein Name: | Glutamate receptor ionotropic, kainate 3 |
| UniProt Synonym Protein Names: | Excitatory amino acid receptor 5; EAA5; Glutamate receptor 7; GluR-7; GluR7 |
| Protein Family: | Glutamate receptor ionotropic |
| UniProt Gene Name: | GRIK3 |
| UniProt Entry Name: | GRIK3_HUMAN |
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