Signal Transduction Antibodies 2
Anti-GRIA4 Antibody (CAB1492)
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- SKU:
- CAB1492
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GRIA4 Antibody |
| Antibody SKU: | CAB1492 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-433 of human GRIA4 (NP_001070712.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, B cells, Mouse brain, Mouse liver, Mouse kidney, Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-433 of human GRIA4 (NP_001070712.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HGGA NVTG FQLV DFNT PMVI KLMD RWKK LDQR EYPG SETP PKYT SALT YDGV LVMA ETFR SLRR QKID ISRR GNAG DCLA NPAA PWGQ GIDM ERTL KQVR IQGL TGNV QFDH YGRR VNYT MDVF ELKS TGPR KVGY WNDM DKLV LIQD VPTL GNDT AAIE NRTV VVTT IMPL MKNP ILRN |
| Gene ID: | 2893 |
| Uniprot: | P48058 |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, dendrite, postsynaptic cell membrane, synapse |
| Calculated MW: | 49kDa/100kDa |
| Observed MW: | 101kDa |
| Synonyms: | GRIA4, GLUR4, GLUR4C, GLURD, GluA4 |
| Background: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. |
| UniProt Protein Function: | GluR4: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q22 Cellular Component: cell junction; cell soma; dendrite; plasma membrane; postsynaptic membrane; terminal button Molecular Function:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport |
| NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48058 |
| NCBI GenInfo Identifier: | 218512059 |
| NCBI Gene ID: | 2893 |
| NCBI Accession: | P48058.2 |
| UniProt Secondary Accession: | P48058,Q86XE8, |
| UniProt Related Accession: | P48058 |
| Molecular Weight: | 49,146 Da |
| NCBI Full Name: | Glutamate receptor 4 |
| NCBI Synonym Full Names: | glutamate ionotropic receptor AMPA type subunit 4 |
| NCBI Official Symbol: | GRIA4 |
| NCBI Official Synonym Symbols: | GLUR4; GLURD; GluA4; GLUR4C |
| NCBI Protein Information: | glutamate receptor 4 |
| UniProt Protein Name: | Glutamate receptor 4 |
| UniProt Synonym Protein Names: | AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4 |
| Protein Family: | Glutamate receptor |
| UniProt Gene Name: | GRIA4 |
| UniProt Entry Name: | GRIA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRIA4 antibody (CAB1492) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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