Cell Biology Antibodies 13
Anti-GRHPR Antibody (CAB17593)
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- SKU:
- CAB17593
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GRHPR Antibody |
| Antibody SKU: | CAB17593 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-328 of human GRHPR (NP_036335.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | PC-3, HepG2, 293T, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-328 of human GRHPR (NP_036335.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VGYT PDVL TDTT AELA VSLL LTTC RRLP EAIE EVKN GGWT SWKP LWLC GYGL TQST VGII GLGR IGQA IARR LKPF GVQR FLYT GRQP RPEE AAEF QAEF VSTP ELAA QSDF IVVA CSLT PATE GLCN KDFF QKMK ETAV FINI SRGD VVNQ DDLY QALA SGKI AAAG LDVT SPEP LPTN HPLL TLKN CVIL PHIG SATH RTRN TMSL LAAN NLLA GLRG EPMP SELK L |
| Gene ID: | 9380 |
| Uniprot: | Q9UBQ7 |
| Cellular Location: | |
| Calculated MW: | 27kDa/35kDa |
| Observed MW: | 36kDa |
 | Western blot - GRHPR Polyclonal Antibody (CAB17593) |
| Synonyms: | GLXR, GLYD, PH2, GRHPR |
| Background: | This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GRHPR: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; Oxidoreductase; EC 1.1.1.79; EC 1.1.1.81 Chromosomal Location of Human Ortholog: 9q12 Cellular Component: peroxisomal matrix; cytoplasm; cytosol Molecular Function:glyoxylate reductase (NADP) activity; protein homodimerization activity; carboxylic acid binding; hydroxypyruvate reductase activity; NAD binding; glycerate dehydrogenase activity Biological Process: dicarboxylic acid metabolic process; glyoxylate metabolic process; metabolic process; excretion; protein oligomerization Disease: Hyperoxaluria, Primary, Type Ii |
| NCBI Summary: | This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBQ7 |
| NCBI GenInfo Identifier: | 47116943 |
| NCBI Gene ID: | 9380 |
| NCBI Accession: | Q9UBQ7.1 |
| UniProt Related Accession: | Q9UBQ7 |
| Molecular Weight: | |
| NCBI Full Name: | Glyoxylate reductase/hydroxypyruvate reductase |
| NCBI Synonym Full Names: | glyoxylate and hydroxypyruvate reductase |
| NCBI Official Symbol: | GRHPR |
| NCBI Official Synonym Symbols: | PH2; GLXR; GLYD |
| NCBI Protein Information: | glyoxylate reductase/hydroxypyruvate reductase |
| UniProt Protein Name: | Glyoxylate reductase/hydroxypyruvate reductase |
| Protein Family: | Glyoxylate reductase/hydroxypyruvate reductase |
| UniProt Gene Name: | GRHPR |
| UniProt Entry Name: | GRHPR_HUMAN |
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