Cell Biology Antibodies 4
Anti-GREM2 Antibody (CAB14291)
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- SKU:
- CAB14291
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GREM2 Antibody |
| Antibody SKU: | CAB14291 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human GREM2 (NP_071914.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human GREM2 (NP_071914.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFWK LSLS LFLV AVLV KVAE ARKN RPAG AIPS PYKD GSSN NSER WQHQ IKEV LASS QEAL |
| Gene ID: | 64388 |
| Uniprot: | Q9H772 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa |
| Observed MW: | 19kDa |
| Synonyms: | GREM2, CKTSF1B2, DAND3, PRDC, STHAG9, gremlin-2 |
| Background: | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. |
| UniProt Protein Function: | GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q43 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; protein homodimerization activity; cytokine activity Biological Process: BMP signaling pathway; embryonic body morphogenesis; cytokine and chemokine mediated signaling pathway; determination of dorsal identity |
| NCBI Summary: | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H772 |
| NCBI GenInfo Identifier: | 71164892 |
| NCBI Gene ID: | 64388 |
| NCBI Accession: | NP_071914.3 |
| UniProt Secondary Accession: | Q9H772,Q86UD9, |
| UniProt Related Accession: | Q9H772 |
| Molecular Weight: | 19,320 Da |
| NCBI Full Name: | gremlin-2 |
| NCBI Synonym Full Names: | gremlin 2, DAN family BMP antagonist |
| NCBI Official Symbol: | GREM2 |
| NCBI Official Synonym Symbols: | PRDC; DAND3; CKTSF1B2 |
| NCBI Protein Information: | gremlin-2; DAN domain family member 3; protein related to DAN and cerberus; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog |
| UniProt Protein Name: | Gremlin-2 |
| UniProt Synonym Protein Names: | Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus |
| Protein Family: | Gremlin |
| UniProt Gene Name: | GREM2 |
| UniProt Entry Name: | GREM2_HUMAN |
 | Western blot analysis of extracts of mouse brain, using GREM2 antibody (CAB14291) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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