Cell Death Antibodies 2
Anti-Granzyme B Antibody (CAB19592)
(No reviews yet)
Write a Review
- SKU:
- CAB19592
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Granzyme B Antibody |
| Antibody SKU: | CAB19592 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Granzyme B. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | THP-1 |
| Immunogen: | A synthesized peptide derived from human Granzyme B. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3002 |
| Uniprot: | P10144 |
| Cellular Location: | |
| Calculated MW: | 25-35kDa |
| Observed MW: | 29KDa |
 | Western blot - Granzyme B Rabbit mAb (CAB19592) |
| Synonyms: | C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, Granzyme B, GZMB |
| Background: | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] |
| UniProt Protein Function: | GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Apoptosis; EC 3.4.21.79; Protease Chromosomal Location of Human Ortholog: 14q12 Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: apoptosis; natural killer cell mediated cytotoxicity; protein processing |
| NCBI Summary: | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] |
| UniProt Code: | P10144 |
| NCBI GenInfo Identifier: | 317373361 |
| NCBI Gene ID: | 3002 |
| NCBI Accession: | P10144.2 |
| UniProt Secondary Accession: | P10144,Q8N1D2, Q9UCC1, |
| UniProt Related Accession: | P10144 |
| Molecular Weight: | |
| NCBI Full Name: | Granzyme B |
| NCBI Synonym Full Names: | granzyme B |
| NCBI Official Symbol: | GZMB |
| NCBI Official Synonym Symbols: | C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1 |
| NCBI Protein Information: | granzyme B |
| UniProt Protein Name: | Granzyme B |
| UniProt Synonym Protein Names: | C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMB |
Related Products
Granzyme B Monoclonal Antibody
Granzyme B Monoclonal AntibodyThe product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
