| UniProt Protein Function: | GPX5: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Belongs to the glutathione peroxidase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.11.1.9; Secreted, signal peptide; Other Amino Acids Metabolism - glutathione; Oxidoreductase; Lipid Metabolism - arachidonic acid; SecretedChromosomal Location of Human Ortholog: 6p22.1Cellular Component: extracellular spaceMolecular Function: glutathione peroxidase activityBiological Process: response to oxidative stress; lipid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016] |
| UniProt Code: | O75715 |
| NCBI GenInfo Identifier: | 6016164 |
| NCBI Gene ID: | 2880 |
| NCBI Accession: | O75715.1 |
| UniProt Secondary Accession: | O75715,P21765 |
| UniProt Related Accession: | O75715 |
| Molecular Weight: | |
| NCBI Full Name: | Epididymal secretory glutathione peroxidase |
| NCBI Synonym Full Names: | glutathione peroxidase 5 |
| NCBI Official Symbol: | GPX5 |
| NCBI Official Synonym Symbols: | EGLP; GPx-5; GSHPx-5; HEL-S-75p |
| NCBI Protein Information: | epididymal secretory glutathione peroxidase |
| UniProt Protein Name: | Epididymal secretory glutathione peroxidase |
| UniProt Synonym Protein Names: | Epididymis-specific glutathione peroxidase-like protein; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5 |
| Protein Family: | Probable glutathione peroxidase |
| UniProt Gene Name: | GPX5 |
| UniProt Entry Name: | GPX5_HUMAN |
