Cell Biology Antibodies 15
Anti-GPS2 Antibody (CAB3901)
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- SKU:
- CAB3901
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GPS2 Antibody |
| Antibody SKU: | CAB3901 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of mouse GPS2 (NP_062700.2). |
| Application: | WB IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IP 1:20 - 1:50 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SKOV3, A-431, SGC-7901, BxPC-3, Mouse lung, Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of mouse GPS2 (NP_062700.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TQPA YSPS QQLR APSA FPAV QYLS QPQP QPYA VHGH FQPT QTGF LQPG STLS LQKQ MEHA NQQT SFSD SSSL RPMH PQAL HPAP GLLA SPQL PVQI QAAG KSGF ATTS QPGP RLPF IQHS QNPR FYHK |
| Gene ID: | 56310 |
| Uniprot: | |
| Cellular Location: | |
| Calculated MW: | 20kDa |
| Observed MW: | 37kDa |
| Synonyms: | GPS2, AMF-1 |
| Background: | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. |
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