Cell Biology Antibodies 10
Anti-GPS1 Antibody (CAB6917)
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- SKU:
- CAB6917
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GPS1 Antibody |
| Antibody SKU: | CAB6917 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human GPS1 (NP_997657.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, SKOV3, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human GPS1 (NP_997657.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VSKA ESTP EIAE QRGE RDSQ TQAI LTKL KCAA GLAE LAAR KYKQ AAKC LLLA SFDH CDFP ELLS PSNV AIYG GLCA LATF DRQE LQRN VISS SSFK LFLE LEPQ VRDI IFKF YESK YASC LKML DEMK DNLL LDMY LAPH VRTL YTQI RNRA LIQY FSPY VSAD MHRM AAAF NTTV AALE DELT QLIL EGLI SARV DSHS KILY ARDV DQRS TTFE KSLL MGKE FQRR AKAM MLRA AVLR NQIH VKSP PREG SQGE LTPA NSQS RMST NM |
| Gene ID: | 2873 |
| Uniprot: | Q13098 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 55kDa/59kDa |
| Observed MW: | 55kDa |
| Synonyms: | GPS1, COPS1, CSN1, SGN1 |
| Background: | This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. |
| UniProt Protein Function: | COPS1: a protein that suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. |
| UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: signalosome; cytoplasm; nucleus Molecular Function:protein binding; GTPase inhibitor activity Biological Process: cullin deneddylation; JNK cascade; cell cycle; inactivation of MAPK activity |
| NCBI Summary: | This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13098 |
| NCBI GenInfo Identifier: | 223590263 |
| NCBI Gene ID: | 2873 |
| NCBI Accession: | Q13098.4 |
| UniProt Secondary Accession: | Q13098,Q8NA10, Q9BWL1, |
| UniProt Related Accession: | Q13098 |
| Molecular Weight: | 491 |
| NCBI Full Name: | COP9 signalosome complex subunit 1 |
| NCBI Synonym Full Names: | G protein pathway suppressor 1 |
| NCBI Official Symbol: | GPS1 |
| NCBI Official Synonym Symbols: | CSN1; COPS1 |
| NCBI Protein Information: | COP9 signalosome complex subunit 1; SGN1; GPS-1; signalosome subunit 1; COP9 signalosome subunit 1; JAB1-containing signalosome subunit 1 |
| UniProt Protein Name: | COP9 signalosome complex subunit 1 |
| UniProt Synonym Protein Names: | G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH |
| UniProt Gene Name: | GPS1 |
| UniProt Entry Name: | CSN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPS1 antibody (CAB6917) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human kidney using GPS1 antibody (CAB6917) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using GPS1 antibody (CAB6917) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse cancer using GPS1 antibody (CAB6917) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF7 cells using GPS1 antibody (CAB6917). |
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