Cell Biology Antibodies 12

Anti-GPRC5A Antibody (CAB8173)

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SKU:
CAB8173
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:GPRC5A Rabbit Polyclonal Antibody
Antibody SKU:CAB8173
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 258-357 of human GPRC5A (NP_003970.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:Mouse lung, Mouse kidney, Mouse stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 258-357 of human GPRC5A (NP_003970.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LAYV SPEF WLLT KQRN PMDY PVED AFCK PQLV KKSY GVEN RAYS QEEI TQGF EETG DTLY APYS THFQ LQNQ PPQK EFSI PRAH AWPS PYKD YEVK KEGS
Gene ID:9052
Uniprot:Q8NFJ5
Cellular Location:Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein
Calculated MW:40kDa
Observed MW:41kDa
Synonyms:GPRC5A, GPCR5A, PEIG-1, RAI3, RAIG1, TIG1
Background:This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.
UniProt Protein Function:RAIG1: a G protein coupled receptor that is induced by all-trans retinoic acid (ATRA). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. RAIG1 is expressed in lung tissue and in several lung cancer cell lines. This retinoic acid-inducible GPCR provides evidence for an interaction between retinoid and G-protein signaling pathways.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 3; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function:G-protein coupled receptor activity; protein binding

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of epidermal growth factor receptor activity; signal transduction

NCBI Summary:This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NFJ5
NCBI GenInfo Identifier:46396943
NCBI Gene ID:9052
NCBI Accession:Q8NFJ5.2
UniProt Secondary Accession:Q8NFJ5,O95357, B3KV45,
UniProt Related Accession:Q8NFJ5
Molecular Weight:40,251 Da
NCBI Full Name:Retinoic acid-induced protein 3
NCBI Synonym Full Names:G protein-coupled receptor class C group 5 member A
NCBI Official Symbol:GPRC5A  
NCBI Official Synonym Symbols:RAI3; TIG1; RAIG1; GPCR5A; PEIG-1  
NCBI Protein Information:retinoic acid-induced protein 3
UniProt Protein Name:Retinoic acid-induced protein 3
UniProt Synonym Protein Names:G-protein coupled receptor family C group 5 member A; Phorbol ester induced gene 1
Protein Family:Retinoic acid-induced protein
UniProt Gene Name:GPRC5A  
UniProt Entry Name:RAI3_HUMAN
Anti-GPRC5A Polyclonal Antibody (CAB8173)Western blot analysis of extracts of various cell lines, using GPRC5A antibody (CAB8173) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
Anti-GPRC5A Polyclonal Antibody (CAB8173)Immunohistochemistry of paraffin-embedded human stomach using GPRC5A antibody (CAB8173) at dilution of 1:100 (40x lens).
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