Cell Biology Antibodies 6
Anti-GPRASP1 Antibody (CAB16090)
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- SKU:
- CAB16090
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GPRASP1 Antibody |
| Antibody SKU: | CAB16090 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human GPRASP1 (NP_055525.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Rat eye, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human GPRASP1 (NP_055525.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SSLF WSGD EVTA KFHP GNRV KDSN RSMH MANQ EANT MSRS QTNQ ELYI ASSS GSED ESVK TPWF WARD KTNT WSGP REDP NSRS RFRS KKEV YVES SSGS EHED HLES WFGA GKEA KFRS KMRA GKEA NNRA RHRA KREA CIDF MPGS IDVI KKES CFWP EENA NTFS RPMI KKEA RARA MTKE EAKT KARA RAKQ EARS EEEA LIGT WFWA TDES SMAD EASI ESSL QVED ESII GSWF WTEE EASM GTGA SSKS RPRT DGER IGDS LFGA REKT SMKT GAEA TSES ILAA DDEQ VIIG S |
| Gene ID: | 9737 |
| Uniprot: | Q5JY77 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 156kDa |
| Observed MW: | 157kDa |
| Synonyms: | GPRASP1, GASP, GASP-1, GASP1 |
| Background: | This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. |
| UniProt Protein Function: | GPRASP1: May modulate lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes. Belongs to the GPRASP family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: Xq22.1 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: endosome to lysosome transport |
| NCBI Summary: | This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010] |
| UniProt Code: | Q5JY77 |
| NCBI GenInfo Identifier: | 150378489 |
| NCBI Gene ID: | 9737 |
| NCBI Accession: | NP_001092880.1 |
| UniProt Secondary Accession: | Q5JY77,O43168, Q96LA1, |
| UniProt Related Accession: | Q5JY77 |
| Molecular Weight: | 55-66 kDa |
| NCBI Full Name: | G-protein coupled receptor-associated sorting protein 1 |
| NCBI Synonym Full Names: | G protein-coupled receptor associated sorting protein 1 |
| NCBI Official Symbol: | GPRASP1 |
| NCBI Official Synonym Symbols: | GASP; GASP1; GASP-1 |
| NCBI Protein Information: | G-protein coupled receptor-associated sorting protein 1 |
| UniProt Protein Name: | G-protein coupled receptor-associated sorting protein 1 |
| UniProt Gene Name: | GPRASP1 |
| UniProt Entry Name: | GASP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPRASP1 antibody (CAB16090) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using GPRASP1 antibody (CAB16090) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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