Name: Anti-GPR65 Antibody (CAB18397)
Brand: Cell Biology Antibodies 18
SKU: CAB18397
Availability: OutOfStock

Antibody Name:	Anti-GPR65 Antibody
Antibody SKU:	CAB18397
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human GPR65.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:

Immunogen:	A synthetic peptide of human GPR65.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	8477
Uniprot:	Q5VT25
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:	TDAG8, hTDAG8, GPR65
Background:

UniProt Protein Function:	MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; GEK subfamily Chromosomal Location of Human Ortholog: 1q42.11 Cellular Component: cytoplasm; leading edge; actomyosin; intercellular junction Molecular Function:identical protein binding; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation
NCBI Summary:	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
UniProt Code:	Q5VT25
NCBI GenInfo Identifier:	30089962
NCBI Gene ID:	8476
NCBI Accession:	NP_003598.2
UniProt Related Accession:	Q5VT25
Molecular Weight:
NCBI Full Name:	serine/threonine-protein kinase MRCK alpha isoform B
NCBI Synonym Full Names:	CDC42 binding protein kinase alpha
NCBI Official Symbol:	CDC42BPA
NCBI Official Synonym Symbols:	MRCK; MRCKA; PK428
NCBI Protein Information:	serine/threonine-protein kinase MRCK alpha
UniProt Protein Name:	Serine/threonine-protein kinase MRCK alpha
UniProt Synonym Protein Names:	CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha
UniProt Gene Name:	CDC42BPA
UniProt Entry Name:	MRCKA_HUMAN