Cell Biology Antibodies 18

Anti-GPR65 Antibody (CAB18397)

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SKU:
CAB18397
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GPR65 Antibody
Antibody SKU:CAB18397
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human GPR65.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide of human GPR65.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8477
Uniprot:Q5VT25
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:TDAG8, hTDAG8, GPR65
Background:
UniProt Protein Function:MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; GEK subfamily

Chromosomal Location of Human Ortholog: 1q42.11

Cellular Component: cytoplasm; leading edge; actomyosin; intercellular junction

Molecular Function:identical protein binding; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation

NCBI Summary:The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
UniProt Code:Q5VT25
NCBI GenInfo Identifier:30089962
NCBI Gene ID:8476
NCBI Accession:NP_003598.2
UniProt Related Accession:Q5VT25
Molecular Weight:
NCBI Full Name:serine/threonine-protein kinase MRCK alpha isoform B
NCBI Synonym Full Names:CDC42 binding protein kinase alpha
NCBI Official Symbol:CDC42BPA  
NCBI Official Synonym Symbols:MRCK; MRCKA; PK428  
NCBI Protein Information:serine/threonine-protein kinase MRCK alpha
UniProt Protein Name:Serine/threonine-protein kinase MRCK alpha
UniProt Synonym Protein Names:CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha
UniProt Gene Name:CDC42BPA  
UniProt Entry Name:MRCKA_HUMAN
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