| UniProt Protein Function: | G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand. Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand. Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4+ dendritic cells in bridging channels. Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2). |
| NCBI Summary: | This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32249 |
| NCBI GenInfo Identifier: | 4826706 |
| NCBI Gene ID: | 1880 |
| NCBI Accession: | NP_004942.1 |
| UniProt Secondary Accession: | P32249,Q53F99, Q5JUH7, B2R8N5, |
| UniProt Related Accession: | P32249 |
| Molecular Weight: | 41 kDa |
| NCBI Full Name: | G-protein coupled receptor 183 |
| NCBI Synonym Full Names: | G protein-coupled receptor 183 |
| NCBI Official Symbol: | GPR183 |
| NCBI Official Synonym Symbols: | EBI2; hEBI2 |
| NCBI Protein Information: | G-protein coupled receptor 183 |
| UniProt Protein Name: | G-protein coupled receptor 183 |
| UniProt Synonym Protein Names: | Epstein-Barr virus-induced G-protein coupled receptor 2 |
| UniProt Gene Name: | GPR183 |
