Cell Biology Antibodies 1

Anti-GPR126 Antibody (CAB10318)

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SKU:
CAB10318
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GPR126 Antibody
Antibody SKU:CAB10318
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GPR126 (NP_001027567.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GPR126 (NP_001027567.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NCRV VLSN PSGT FTSP CYPN DYPN SQAC MWTL RAPT GYII QITF NDFD IEEA PNCI YDSL SLDN GESQ TKFC GATA KGLS FNSS ANEM HVSF SSDF SIQK KGFN ASYI RVAV SLRN QKVI LPQT SDAY QVSV AKSI SIPE LSAF TLCF EATK VGHE DSDW TAFS YSNA SFTQ LLSF GKAK SGYF LSIS DSKC LLNN ALPV KEKE DIFA ESFE QLCL VWNN SLGS IGVN FKRN YETV PCDS TISK VIPG NGKL LLGS NQNE I
Gene ID:57211
Uniprot:Q86SQ4
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:133kDa/136kDa/139kDa
Observed MW:160kDa
Synonyms:ADGRG6, APG1, DREG, GPR126, LCCS9, PR126, PS1TP2, VIGR, STQTL1
Background:This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene.
UniProt Protein Function:G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
NCBI Summary:This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Code:Q86SQ4
NCBI GenInfo Identifier:215274152
NCBI Gene ID:57211
NCBI Accession:Q86SQ4.3
UniProt Secondary Accession:Q86SQ4,Q5TGN7, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8 Q6MZU7, Q8IXA4, Q8NC14, Q96JW0,
UniProt Related Accession:Q86SQ4
Molecular Weight:137kDa
NCBI Full Name:Adhesion G-protein coupled receptor G6
NCBI Synonym Full Names:adhesion G protein-coupled receptor G6
NCBI Official Symbol:ADGRG6  
NCBI Official Synonym Symbols:APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2  
NCBI Protein Information:adhesion G-protein coupled receptor G6; G-protein coupled receptor 126
UniProt Protein Name:Adhesion G-protein coupled receptor G6
UniProt Synonym Protein Names:Developmentally regulated G-protein-coupled receptor
Protein Family:G-protein coupled receptor
UniProt Gene Name:ADGRG6  
Anti-GPR126 Antibody (CAB10318)Western blot analysis of extracts of mouse heart, using GPR126 antibody (CAB10318) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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